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Volume 31, Supplement—May 2025

SUPPLEMENT ISSUE
Supplement

Lessons from 5 Years of Routine Whole-Genome Sequencing for Epidemiologic Surveillance of Shiga Toxin–Producing Escherichia coli, France, 2018–2022

Gabrielle JonesComments to Author , Carolina Silva Nodari, Laëtitia Fabre, Henriette de Valk, Harold Noel, Aurélie Cointe, Stéphane Bonacorsi, François-Xavier Weill, and Yann Le Strat
Author affiliation: Santé publique France, Saint-Maurice, France (G. Jones, H. de Valk, H. Noel, Y. Le Strat); Institut Pasteur, Université Paris Cité, Paris, France (C. Silva Nodari, L. Fabre, F.-X. Weill); Centre hospitalier universitaire Robert Debré, Assistance Publique–Hôpitaux de Paris, Paris (A. Cointe, S. Bonacorsi)

Main Article

Figure 4

Regression from hierarchical clustering at a threshold of 5 allelic differences from 5 years of routine whole-genome sequencing for epidemiologic surveillance of Shiga toxin–producing Escherichia coli, France, 2018–2022. A) Allelic distance; B) SNP distance. Distances calculated as a function of time in days by multivariable fractional polynomial linear regression. Black circles indicate estimated allelic or SNP distance for each observed temporal distance in days; blue, red, green, and black vertical lines, 95% CIs of the estimated genomic distances for each observed temporal distance in days. SNP, single-nucleotide polymorphism.

Figure 4. Regression from hierarchical clustering at a threshold of 5 allelic differences from 5 years of routine whole-genome sequencing for epidemiologic surveillance of Shiga toxin–producing Escherichia coli, France, 2018–2022. A) Allelic distance; B) SNP distance. Distances calculated as a function of time in days by multivariable fractional polynomial linear regression. Black circles indicate estimated allelic or SNP distance for each observed temporal distance in days; blue, red, green, and black vertical lines, 95% CIs of the estimated genomic distances for each observed temporal distance in days. SNP, single-nucleotide polymorphism.

Main Article

Page created: April 08, 2025
Page updated: May 12, 2025
Page reviewed: May 12, 2025
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