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Volume 31, Number 2—February 2025
Dispatch

Infection by Tickborne Bacterium Candidatus Midichloria Associated with First Trimester Pregnancy Loss, Tennessee, USA

John Newman, Caitlin Hughes, Karen C. Bloch, Khalil J. Deveaux, Scott Allen, Thao T. Truong, Behzad Najafian, Abelardo C. Moncayo, Lili Tao, Joshua Lieberman, and Hernán CorreaComments to Author 
Author affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA (J. Newman, C. Hughes, K.C. Bloch, L. Tao, H. Correa); University of Washington School of Medicine, Seattle, Washington, USA (K.J. Deveaux, S. Allen, T.T. Truong, B. Najafian, J. Lieberman); Tennessee Department of Health, Nashville (A.C. Moncayo)

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Figure 2

Imaging of samples from patient in study of infection by tickborne bacterium Candidatus Midichloria associated with first trimester pregnancy loss, Tennessee, USA. A, B) Formalin-fixed paraffin-embedded sections showing acute suppurative villitis and large intravillous abscesses. Original magnification ×40 for panel A and ×200 for panel B. C, D) Electron microscopy analysis was performed on tissue that was previously formalin-fixed but not paraffin-embedded. The formalin-fixed tissue was placed in a 2.5% glutaraldehyde solution before electron microscopy analysis. C) Intracellular bacterial forms in the cytosol (indicated by arrows) at ×20,000 magnification; D) cytoplasmic vacuoles (indicated by arrows) at ×60,000 magnification, measuring ≈0.25–0.34 μm × 0.40–0.53 μm.

Figure 2. Imaging of samples from patient in study of infection by tickborne bacterium Candidatus Midichloria associated with first trimester pregnancy loss, Tennessee, USA. A, B) Formalin-fixed paraffin-embedded sections showing acute suppurative villitis and large intravillous abscesses. Original magnification ×40 for panel A and ×200 for panel B. C, D) Electron microscopy analysis was performed on tissue that was previously formalin-fixed but not paraffin-embedded. The formalin-fixed tissue was placed in a 2.5% glutaraldehyde solution before electron microscopy analysis. C) Intracellular bacterial forms in the cytosol (indicated by arrows) at ×20,000 magnification; D) cytoplasmic vacuoles (indicated by arrows) at ×60,000 magnification, measuring ≈0.25–0.34 μm × 0.40–0.53 μm.

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Page created: December 06, 2024
Page updated: January 31, 2025
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