Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 2—February 2025
Dispatch

Infection by Tickborne Bacterium Candidatus Midichloria Associated with First Trimester Pregnancy Loss, Tennessee, USA

John Newman, Caitlin Hughes, Karen C. Bloch, Khalil J. Deveaux, Scott Allen, Thao T. Truong, Behzad Najafian, Abelardo C. Moncayo, Lili Tao, Joshua Lieberman, and Hernán CorreaComments to Author 
Author affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA (J. Newman, C. Hughes, K.C. Bloch, L. Tao, H. Correa); University of Washington School of Medicine, Seattle, Washington, USA (K.J. Deveaux, S. Allen, T.T. Truong, B. Najafian, J. Lieberman); Tennessee Department of Health, Nashville (A.C. Moncayo)

Main Article

Figure 2

Imaging of samples from patient in study of infection by tickborne bacterium Candidatus Midichloria associated with first trimester pregnancy loss, Tennessee, USA. A, B) Formalin-fixed paraffin-embedded sections showing acute suppurative villitis and large intravillous abscesses. Original magnification ×40 for panel A and ×200 for panel B. C, D) Electron microscopy analysis was performed on tissue that was previously formalin-fixed but not paraffin-embedded. The formalin-fixed tissue was placed in a 2.5% glutaraldehyde solution before electron microscopy analysis. C) Intracellular bacterial forms in the cytosol (indicated by arrows) at ×20,000 magnification; D) cytoplasmic vacuoles (indicated by arrows) at ×60,000 magnification, measuring ≈0.25–0.34 μm × 0.40–0.53 μm.

Figure 2. Imaging of samples from patient in study of infection by tickborne bacterium Candidatus Midichloria associated with first trimester pregnancy loss, Tennessee, USA. A, B) Formalin-fixed paraffin-embedded sections showing acute suppurative villitis and large intravillous abscesses. Original magnification ×40 for panel A and ×200 for panel B. C, D) Electron microscopy analysis was performed on tissue that was previously formalin-fixed but not paraffin-embedded. The formalin-fixed tissue was placed in a 2.5% glutaraldehyde solution before electron microscopy analysis. C) Intracellular bacterial forms in the cytosol (indicated by arrows) at ×20,000 magnification; D) cytoplasmic vacuoles (indicated by arrows) at ×60,000 magnification, measuring ≈0.25–0.34 μm × 0.40–0.53 μm.

Main Article

Page created: December 06, 2024
Page updated: January 31, 2025
Page reviewed: January 31, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external