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Volume 31, Number 4—April 2025
Research

Prevalence of Herpes B Virus in Wild Long-Tailed Macaques, Thailand, 2018–2024

Krittiga Sapkanarak, Jiro Yasuda, Murasaki Amano, Suthirote Meesawat, Taratorn Kemthong, Titiporn Kaikaew, and Suchinda Malaivijitnond
Author affiliation: Chulalongkorn University, Bangkok, Thailand (K. Sapkanarak, T. Kaikaew, S. Malaivijitnond); Nagasaki University, Nagasaki, Japan (J. Yasuda, M. Amano); National Primate Research Center of Thailand, Saraburi, Thailand (S. Meesawat, T. Kemthong, S. Malaivijitnond)

Main Article

Figure 2

Distribution of 6 virus-positive wild long-tailed macaque populations in study of prevalence of herpes B virus in Thailand, 2018–2024. Dark gray shading indicates distribution of Macaca fascicularis subspecies aurea macaques; light gray shading indicates geographic range of M. fascicularis subsp. fascicularis macaques. Red text indicates locations of macaques BTB14 and MFRC17 described previously (14). BTB, Bang Ta Boon; CAO, Wat Tham Khao Cha Ang On; MFRC, Mangrove Forest Research Center; TPK, Tham Pra Khayang; WKN, Wat KuPhra Ko Na; WTT, Wat Tham Thep Ban Dan.

Figure 2. Distribution of 6 virus-positive wild long-tailed macaque populations in study of prevalence of herpes B virus in Thailand, 2018–2024. Dark gray shading indicates distribution of Macaca fascicularis subspecies aurea macaques; light gray shading indicates geographic range of M. fascicularis subsp. fascicularis macaques. Red text indicates locations of macaques BTB14 and MFRC17 described previously (14). BTB, Bang Ta Boon; CAO, Wat Tham Khao Cha Ang On; MFRC, Mangrove Forest Research Center; TPK, Tham Pra Khayang; WKN, Wat KuPhra Ko Na; WTT, Wat Tham Thep Ban Dan.

Main Article

References
  1. Smith  AL, Black  DH, Eberle  R. Molecular evidence for distinct genotypes of monkey B virus (herpesvirus simiae) which are related to the macaque host species. J Virol. 1998;72:922432. DOIPubMedGoogle Scholar
  2. Weigler  BJ. Biology of B virus in macaque and human hosts: a review. Clin Infect Dis. 1992;14:55567. DOIPubMedGoogle Scholar
  3. Perelygina  L, Zhu  L, Zurkuhlen  H, Mills  R, Borodovsky  M, Hilliard  JK. Complete sequence and comparative analysis of the genome of herpes B virus (Cercopithecine herpesvirus 1) from a rhesus monkey. J Virol. 2003;77:616777. DOIPubMedGoogle Scholar
  4. Weigler  BJ, Scinicariello  F, Hilliard  JK. Risk of venereal B virus (cercopithecine herpesvirus 1) transmission in rhesus monkeys using molecular epidemiology. J Infect Dis. 1995;171:113943. DOIPubMedGoogle Scholar
  5. DuRaine  G, Johnson  DC. Anterograde transport of α-herpesviruses in neuronal axons. Virology. 2021;559:6573. DOIPubMedGoogle Scholar
  6. Lees  DN, Baskerville  A, Cropper  LM, Brown  DW. Herpesvirus simiae (B virus) antibody response and virus shedding in experimental primary infection of cynomolgus monkeys. Lab Anim Sci. 1991;41:3604.PubMedGoogle Scholar
  7. Wisely  SM, Sayler  KA, Anderson  CJ, Boyce  CL, Klegarth  AR, Johnson  SA. Macacine herpesvirus 1 antibody prevalence and DNA shedding among invasive rhesus macaques, Silver Springs State Park, Florida, USA. Emerg Infect Dis. 2018;24:34551. DOIPubMedGoogle Scholar
  8. Weigler  BJ, Roberts  JA, Hird  DW, Lerche  NW, Hilliard  JK. A cross sectional survey for B virus antibody in a colony of group housed rhesus macaques. Lab Anim Sci. 1990;40:25761.PubMedGoogle Scholar
  9. Lee  MH, Rostal  MK, Hughes  T, Sitam  F, Lee  CY, Japning  J, et al. Macacine herpesvirus 1 in long-tailed macaques, Malaysia, 2009–2011. Emerg Infect Dis. 2015;21:110713. DOIPubMedGoogle Scholar
  10. Eberle  R, Jones-Engel  L. Questioning the extreme neurovirulence of monkey B virus (Macacine alphaherpesvirus 1). Adv Virol. 2018;2018:5248420. DOIPubMedGoogle Scholar
  11. Cohen  JI, Davenport  DS, Stewart  JA, Deitchman  S, Hilliard  JK, Chapman  LE; B Virus Working Group. Recommendations for prevention of and therapy for exposure to B virus (cercopithecine herpesvirus 1). Clin Infect Dis. 2002;35:1191203. DOIPubMedGoogle Scholar
  12. Wang  W, Qi  W, Liu  J, Du  H, Zhao  L, Zheng  Y, et al. First human infection case of monkey B virus identified in China, 2021. China CDC Wkly. 2021;3:6323. DOIPubMedGoogle Scholar
  13. Hu  G, Du  H, Liu  Y, Wu  G, Han  J. Herpes B virus: history, zoonotic potential, and public health implications. Biosaf Health. 2022;4:2139. DOIGoogle Scholar
  14. Amano  M, Sapkanarak  K, Thbthimthong  W, Meesawat  S, Kemthong  T, Suttisan  N, et al. Development of quantitative real-time PCR and loop-mediated isothermal amplification assays for the surveillance and diagnosis of herpes B virus infection. Viruses. 2023;15:2086. DOIPubMedGoogle Scholar
  15. Malaivijitnond  S, Hamada  Y. Current situation and status of long-tailed macaques (Macaca fascicularis) in Thailand. Nat Hist J Chulalongkorn Univ. 2008;8:185204.
  16. Juttuporn  A, Hengpraprom  S, Rattananupong  T. Incidences and characteristics of monkey-related injuries among locals and tourists in Mueng District, Lopburi Province, 2013–2017. Chula Med J. 2020;64:2937. DOIGoogle Scholar
  17. Piyaphanee  W, Kittitrakul  C, Lawpoolsri  S, Gautret  P, Kashino  W, Tangkanakul  W, et al. Risk of potentially rabid animal exposure among foreign travelers in Southeast Asia. PLoS Negl Trop Dis. 2012;6:e1852. DOIPubMedGoogle Scholar
  18. Bunlungsup  S, Imai  H, Hamada  Y, Gumert  MD, San  AM, Malaivijitnond  S. Morphological characteristics and genetic diversity of Burmese long-tailed Macaques (Macaca fascicularis aurea). Am J Primatol. 2016;78:44155. DOIPubMedGoogle Scholar
  19. Matsudaira  K, Hamada  Y, Bunlungsup  S, Ishida  T, San  AM, Malaivijitnond  S. Whole mitochondrial genomic and Y-chromosomal phylogenies of Burmese long-tailed macaque (Macaca fascicularis aurea) suggest ancient hybridization between fascicularis and sinica species groups. J Hered. 2018;109:36071. DOIPubMedGoogle Scholar
  20. Phadphon  P, Kanthaswamy  S, Oldt  RF, Hamada  Y, Malaivijitnond  S. Population Structure of Macaca fascicularis aurea, and their Genetic Relationships with M. f. fascicularis and M. mulatta Determined by 868 RADseq-Derived Autosomal SNPs-A consideration for biomedical research. J Med Primatol. 2022;51:3344. DOIPubMedGoogle Scholar
  21. Kaewchot  S, Tangsudjai  S, Sariya  L, Mongkolphan  C, Saechin  A, Sariwongchan  R, et al. Zoonotic pathogens survey in free-living long-tailed macaques in Thailand. Int J Vet Sci Med. 2022;10:118. DOIPubMedGoogle Scholar
  22. Bunlungsup  S, Imai  H, Hamada  Y, Matsudaira  K, Malaivijitnond  S. Mitochondrial DNA and two Y-chromosome genes of common long-tailed macaques (Macaca fascicularis fascicularis) throughout Thailand and vicinity. Am J Primatol. 2017;79:113. DOIPubMedGoogle Scholar
  23. Bunlungsup  S, Kanthaswamy  S, Oldt  RF, Smith  DG, Houghton  P, Hamada  Y, et al. Genetic analysis of samples from wild populations opens new perspectives on hybridization between long-tailed (Macaca fascicularis) and rhesus macaques (Macaca mulatta). Am J Primatol. 2017;79:e22726. DOIPubMedGoogle Scholar
  24. Meesawat  S, Warit  S, Hamada  Y, Malaivijitnond  S. Prevalence of Mycobacterium tuberculosis complex among wild rhesus macaques and 2 subspecies of long-tailed macaques, Thailand, 2018–2022. Emerg Infect Dis. 2023;29:55160. DOIPubMedGoogle Scholar
  25. Smith  BH, Crummett  TL, Brandt  KL. Ages of eruption of primate teeth: a compendium for aging individuals and comparing life histories. Am J Phys Anthropol. 1994;37(S19):177231. DOIGoogle Scholar
  26. Carlson  CS, O’Sullivan  MG, Jayo  MJ, Anderson  DK, Harber  ES, Jerome  WG, et al. Fatal disseminated cercopithecine herpesvirus 1 (herpes B infection in cynomolgus monkeys (Macaca fascicularis). Vet Pathol. 1997;34:40514. DOIPubMedGoogle Scholar
  27. Katz  D, Shi  W, Patrusheva  I, Perelygina  L, Gowda  MS, Krug  PW, et al. An automated ELISA using recombinant antigens for serologic diagnosis of B virus infections in macaques. Comp Med. 2012;62:52734.PubMedGoogle Scholar
  28. Jensen  K, Alvarado-Ramy  F, González-Martínez  J, Kraiselburd  E, Rullán  J. B-virus and free-ranging macaques, Puerto Rico. Emerg Infect Dis. 2004;10:4946. DOIPubMedGoogle Scholar
  29. Jones-Engel  L, Engel  GA, Heidrich  J, Chalise  M, Poudel  N, Viscidi  R, et al. Temple monkeys and health implications of commensalism, Kathmandu, Nepal. Emerg Infect Dis. 2006;12:9006. DOIPubMedGoogle Scholar
  30. Engel  GA, Jones-Engel  L, Schillaci  MA, Suaryana  KG, Putra  A, Fuentes  A, et al. Human exposure to herpesvirus B-seropositive macaques, Bali, Indonesia. Emerg Infect Dis. 2002;8:78995. DOIPubMedGoogle Scholar
  31. Rohrman  M. Macacine herpes virus (B virus). Workplace Health Saf. 2016;64:912. DOIPubMedGoogle Scholar
  32. Sariol  CA, González-Martínez  J, Arana  T, Gascot  S, Suárez  E, Maldonado  E, et al. Differential distribution of antibodies to different viruses in young animals in the free-ranging rhesus macaques of Cayo Santiago. J Med Primatol. 2006;35:36975. DOIPubMedGoogle Scholar
  33. Huff  JL, Eberle  R, Capitanio  J, Zhou  SS, Barry  PA. Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques. J Gen Virol. 2003;84:8392. DOIPubMedGoogle Scholar
  34. Oya  C, Ochiai  Y, Taniuchi  Y, Takano  T, Fujima  A, Ueda  F, et al. Prevalence of herpes B virus genome in the trigeminal ganglia of seropositive cynomolgus macaques. Lab Anim. 2008;42:99103. DOIPubMedGoogle Scholar
  35. Verma  A, Zaheer  A, Bisht  K, Gaidhane  AM, Khatib  MN, Sah  S, et al. Hong Kong’s first human case of B virus: Feeding monkeys, a risky practice! New Microbes New Infect. 2024;62:101456. DOIPubMedGoogle Scholar
  36. Branda  F, Ciccozzi  A, Giovanetti  M, Romano  C, Ciccozzi  M, Scarpa  F. Another potential zoonotic threat? Herpes B virus in the spotlight. New Microbes New Infect. 2024;60-61:101422. DOIPubMedGoogle Scholar
  37. Hamada  Y, San  AM, Malaivijitnond  S. Assessment of the hybridization between rhesus (Macaca mulatta) and long-tailed macaques (M. fascicularis) based on morphological characters. Am J Phys Anthropol. 2016;159:18998. DOIPubMedGoogle Scholar
  38. Ito  T, Kanthaswamy  S, Bunlungsup  S, Oldt  RF, Houghton  P, Hamada  Y, et al. Secondary contact and genomic admixture between rhesus and long-tailed macaques in the Indochina Peninsula. J Evol Biol. 2020;33:116479. DOIPubMedGoogle Scholar
  39. Kumpai  P, Hamada  Y, Kanthaswamy  S, Malaivijitnond  S. Gene flow from rhesus (Macaca mulatta) to cynomolgus macaques (M. fascicularis) and effects of introgressive hybridization on reproduction in two biomedically relevant non-human primate species. J Med Primatol. 2022;51:10818. DOIPubMedGoogle Scholar

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Page updated: March 07, 2025
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