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Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 6—June 2025

Research

Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan, 2022

Kengo Tokunaga1Comments to Author , Emiko Rimbara1Comments to Author , Toshihisa Tsukadaira, Katsuhiro Mabe, Koji Yahara, Hidekazu Suzuki, Tadashi Shimoyama, Mitsushige Sugimoto, Tadayoshi Okimoto, Hidenori Matsui, Masato Suzuki, Keigo Shibayama, Hiroyoshi Ota, Kazunari Murakami, and Mototsugu Kato
Author affiliation: Kyorin University School of Medicine, Tokyo, Japan (K. Tokunaga); National Institute of Infectious Diseases, Tokyo (E. Rimbara, K. Yahara, H. Matsui, M. Suzuki); Kenwakai Hospital, Iida, Japan (T. Tsukadaira); Mabe Goryokaku Gastrointestinal Endoscopy Clinic, Hakodate, Japan (K. Mabe); Tokai University School of Medicine, Isehara, Japan (H. Suzuki); Aomori General Health Examination Center, Aomori, Japan (T. Shimoyama); Oita University, Oita, Japan (M. Sugimoto, K. Murakami); Oita Prefectural Hospital, Oita (T. Okimoto); Nagoya University Graduate School of Medicine, Nagoya, Japan (K. Shibayama); Shinshu University School of Medicine, Matsumoto, Japan (H. Ota); Public Interest Foundation Hokkaido Cancer Society, Sapporo, Japan (M. Kato)

Main Article

Figure 2

Comparison of patient groups stratified by gastric Helicobacter infection status in study of NHPH infections, Japan, 2022. A) Percentage of men and women in each group. All patients in the H. suis infection group were men. Prevalence of the male sex was significantly higher in the H. suis infection group than in the no Helicobacter infection (59.3%), H. pylori infection (47.6%), posteradication (54.7%), and non–H. suis NHPH infection (50.0%) groups. B) Percentages of patients categorized by each atrophic grade were compared between groups stratified by gastric Helicobacter infection status. In the H. suis infected group, 71.4% were C-2, with no higher grade of atrophy. C-0, no atrophy; C-1 and C-2, mild atrophy; C-3 and O-1, moderate atrophy; O-2 and O-3, severe atrophy. C) Percentages of patients who had no history of pets or who had a history of having pet dogs or cats. No significant differences were observed between the groups, although the proportion of patients with pet cats appeared higher (50%) in the non–H. suis NHPH infection group than in the no Helicobacter infection (19.8%) and H. suis infection (21.4%) groups. D) Patients in each infection group were subdivided into those who sometimes or those who often ingested pork offal. All patients in the H. suis infection group had a history of pork offal ingestion. Prevalence of patients with any history of pork offal ingestion was significantly higher in the H. suis infection group (100%) than in the no Helicobacter infection (61.1%; p = 0.0014), posteradication (53.1%; p = 0.0003), and non–H. suis NHPH infection (50.0%; p = 0.0175) groups. NHPH, non–H. pylori Helicobacter.

Figure 2. Comparison of patient groups stratified by gastric Helicobacter infection status in study of NHPH infections, Japan, 2022. A) Percentage of men and women in each group. All patients in the H. suis infection group were men. Prevalence of the male sex was significantly higher in the H. suis infection group than in the no Helicobacter infection (59.3%), H. pylori infection (47.6%), posteradication (54.7%), and non–H. suis NHPH infection (50.0%) groups. B) Percentages of patients categorized by each atrophic grade were compared between groups stratified by gastric Helicobacter infection status. In the H. suis infected group, 71.4% were C-2, with no higher grade of atrophy. C-0, no atrophy; C-1 and C-2, mild atrophy; C-3 and O-1, moderate atrophy; O-2 and O-3, severe atrophy. C) Percentages of patients who had no history of pets or who had a history of having pet dogs or cats. No significant differences were observed between the groups, although the proportion of patients with pet cats appeared higher (50%) in the non–H. suis NHPH infection group than in the no Helicobacter infection (19.8%) and H. suis infection (21.4%) groups. D) Patients in each infection group were subdivided into those who sometimes or those who often ingested pork offal. All patients in the H. suis infection group had a history of pork offal ingestion. Prevalence of patients with any history of pork offal ingestion was significantly higher in the H. suis infection group (100%) than in the no Helicobacter infection (61.1%; p = 0.0014), posteradication (53.1%; p = 0.0003), and non–H. suis NHPH infection (50.0%; p = 0.0175) groups. NHPH, non–H. pylori Helicobacter.

Main Article

1These authors contributed equally to this article.

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