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Volume 31, Number 6—June 2025

Research

Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan

Kengo Tokunaga1Comments to Author , Emiko Rimbara1Comments to Author , Toshihisa Tsukadaira, Katsuhiro Mabe, Koji Yahara, Hidekazu Suzuki, Tadashi Shimoyama, Mitsushige Sugimoto, Tadayoshi Okimoto, Hidenori Matsui, Masato Suzuki, Keigo Shibayama, Hiroyoshi Ota, Kazunari Murakami, and Mototsugu Kato
Author affiliation: Kyorin University School of Medicine, Tokyo, Japan (K. Tokunaga); National Institute of Infectious Diseases, Tokyo (E. Rimbara, K. Yahara, H. Matsui, M. Suzuki); Kenwakai Hospital, Iida, Japan (T. Tsukadaira); Mabe Goryokaku Gastrointestinal Endoscopy Clinic, Hakodate, Japan (K. Mabe); Tokai University School of Medicine, Isehara, Japan (H. Suzuki); Aomori General Health Examination Center, Aomori, Japan (T. Shimoyama); Oita University, Oita, Japan (M. Sugimoto, K. Murakami); Oita Prefectural Hospital, Oita (T. Okimoto); Nagoya University Graduate School of Medicine, Nagoya, Japan (K. Shibayama); Shinshu University School of Medicine, Matsumoto, Japan (H. Ota); Public Interest Foundation Hokkaido Cancer Society, Sapporo, Japan (M. Kato)

Main Article

Table 3

Comparison of clinical characteristics between groups stratified by gastric Helicobacter species infection status in study of NHPH infections, Japan, 2022*

Characteristics Gastric Helicobacter species infection status
No Helicobacter infection H. pylori infection Posteradication Non–H. suis NHPH infection H. suis infection
Total no. patients
 378
 21
 254
 6
 14
Median age, y (range)
 53 (29–84)
 61 (35–88)
 57 (30–84)
 65 (44–91)
 50 (35–66)
Sex
M 224 (59.3) 10 (47.6) 139 (54.5) 3 (50.0) 14 (100.0)
F
 154 (40.7)
 11 (52.4)
 115 (45.3)
 3 (50.0)
 0
Endoscopic findings
Normal 317 (83.9) 0 5 (2.0) 0 0
Atrophic gastritis 53 (14.0) 21 (100.0) 248 (97.6) 4 (66.7) 14 (100)
Peptic ulcer 0 2 (9.5) 2 (0.8) 1 (16.7) 0
Gastric cancer 2 (0.5) 2 (9.5) 3 (1.2) 0 0
Nodular gastritis 0 4 (19.0) 7 (2.8) 3 (50.0) 6 (42.9)
White marble appearance 15 (4.0) 4 (19.0) 49 (19.3) 1 (16.7) 11 (78.6)
Crack-like mucosa 29 (7.7) 3 (14.3) 22 (8.7) 1 (16.7) 12 (85.7)
White marble appearance or crack-like mucosa
 40 (10.6)
 6 (28.6)
 70 (27.6)
 2 (33.3)
 13 (92.9)
Atrophic grading†
C-0 325 (86.0) 0 6 (2.4) 2 (33.3) 0
C-1 47 (12.4) 2 (9.5) 80 (31.5) 0 4 (28.6)
C-2 5 (1.3) 10 (47.6) 88 (34.6) 3 (50.0) 10 (71.4)
C-3 0 6 (28.6) 31 (12.2) 0 0
O-1 0 1 (4.8) 21 (8.3) 0 0
O-2 0 2 (9.5) 18 (7.1) 1 (16.7) 0
O-3
 1 (0.3)
 0
 10 (3.9)
 0
 0
Pets
No history 128 (33.9) 3 (14.3) 71 (28.0) 2 (33.3) 4 (28.6)
Dog 189 (50.0) 11 (52.4) 145 (57.1) 1 (16.7) 8 (57.1)
Cat
 75 (19.8)
 9 (42.9)
 58 (22.8)
 3 (50.0)
 3 (21.4)
Pork offal ingestion
No history 147 (38.9) 6 (28.6) 119 (46.9) 3 (50.0) 0
Sometimes 206 (54.5) 14 (66.7) 113 (44.5) 2 (33.3) 12 (85.7)
Often 25 (6.6) 1 (4.8) 22 (8.7) 1 (16.7) 2 (14.3)

*Values are no. (%) except as indicated. NHPH, non–Helicobacter pylori Helicobacter. †C-0, no atrophy; C-1 and C-2, mild atrophy; C-3 and O-1, moderate atrophy; and O-2 and O-3, severe atrophy.

Main Article

1These authors contributed equally to this article.

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