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Volume 31, Number 6—June 2025

Research

Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom

Elie Ishara-Nshombo1Comments to Author , Anushri Somasundaran1, Alessandra Romero-Ramirez, Konstantina Kontogianni, Daniel Mukadi-Bamuleka, Marithé Mukoka-Ntumba, Emile Muhindo-Milonde, Hugues Mirimo-Nguee, Jacob Parkes, Yusra Hussain, Susan Gould, Christopher T. Williams, Dominic Wooding, Juvenal Nkeramahame, Mikaela Watson, Hayley E. Hardwick, Malcolm G. Semple, John Kenneth Baillie, Jake Dunning, Thomas E. Fletcher, Thomas Edwards, Devy M. Emperador, Hugo Kavunga-Membo1, Ana Isabel Cubas-Atienzar1Comments to Author , and ISARIC 4 and C Investigators,2
Author affiliation: Rodolphe Mérieux Laboratory, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo (E. Ishara-Nshombo, D. Mukadi-Bamuleka, M. Mukoka-Ntumba, E. Muhindo-Milonde, H. Mirimo-Nguee, H. Kavunga-Membo); Liverpool School of Tropical Medicine, Liverpool, UK (A. Somasundaran, A. Romero-Ramirez, K. Kontogianni, J. Parkes, Y. Hussain, S. Gould, C.T. Williams, D. Wooding, T.E. Fletcher, T. Edwards, A. Cubas-Atienzar); Royal Liverpool University Hospital NHS Foundation Trust, Liverpool (S. Gould, T.E. Fletcher); Foundation for Innovative New Diagnostics, Geneva, Switzerland (J. Nkeramahame, M. Watson, D.M. Emperador); University of Liverpool, Liverpool (H.E. Hardwick, M.G. Semple); University of Edinburgh, Edinburgh, Scotland, UK (J.K. Baillie); Pandemic Sciences Institute, University of Oxford, Oxford, UK (J. Dunning); Royal Free London NHS Foundation Trust, London, UK (J. Dunning)

Main Article

Table 1

Clinical characteristics of recruited mpox patients in study of diagnostic accuracy of 3 mpox lateral flow assays for antigen detection, Democratic Republic of the Congo and United Kingdom*

Characteristic Democratic Republic of the Congo, n = 68 United Kingdom, n = 16
Mean age (range), y
 17 (2–47)
 35.1 (24–58)
Sex
M 34 (50) 16 (100)
F
 34 (50)
 0
Time from symptom onset, d
Median (interquartile range) 4 (3–7) 8 (4.25–12.75)
0–3 32 (47) 1 (6.25)
4–7 22 (32) 6 (37.5)
>8
 14 (21)
 9 (56.25)
Symptoms
Skin lesions 68 (100) 16 (100)
Fever 62 (91) 11 (68.75)
Influenza-like symptoms 51 (75) 4 (25)
Skin rashes 0 14 (87.5)
Headache 37 (54) 4 (25)
Cough 34 (50) 1 (6.25)
Sore throat 25 (37) 4 (25)
Nausea 20 (29) 0
Abdominal pain 19 (28) 0
Chest pain 14 (21) 0
Vomiting 6 (9) 0
Diarrhea 5 (7) 1 (6.25)
Painful Urination 4 (6) 0
Eye discharge 3 (4) 0
Redness of eyes 2 (3) 0

*Values are no. (%) except as indicated.

Main Article

1These authors contributed equally to this article.

2Members of ISARIC 4C investigator group are listed at the end of this article.

Page created: April 08, 2025
Page updated: May 02, 2025
Page reviewed: May 02, 2025
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