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Volume 31, Number 7—July 2025

Research Letter

Genomic Deletion of PfHRP2 and PfHRP3 Antigens in Plasmodium falciparum Strains, Ethiopia, 2009

Tamirat Gebru Woldearegai, Tina Krüger, Sindew Mekasha Feleke, Hassen Mamo, Tesfaye Gelanew, Vanessa Krohmer, Sabine Belard, Peter G. Kremsner, Jana Held, Miriam Rodi, and Andrea KreidenweissComments to Author 
Author affiliation: Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany (T.G. Woldearegai, T. Krüger, V. Krohmer, S. Belard, P.G. Kremsner, J. Held, M. Rodi, A. Kreidenweiss); German Center for Infection Research, partner site Tübingen, Tübingen (T.G. Woldearegai, S. Belard, P.G. Kremsner, J. Held, A. Kreidenweiss); La Trobe University, Melbourne, Victoria, Australia (S.M. Feleke); Ethiopian Public Health Institute, Addis Ababa, Ethiopia (S.M. Feleke); College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa (S.M. Feleke, H. Mamo); Armauer Hansen Research Institute, Addis Ababa (T. Gelanew); Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon (P.G. Kremsner, J. Held, A. Kreidenweiss)

Main Article

Figure

pfhrp2 and pfhrp3 deletion frequency in genomic deletion of PfHRP2 and PfHRP3 antigens in Plasmodium falciparum strains, Ethiopia, 2009. P. falciparum–positive samples from 89 persons, previously identified by species-specific PCR were analyzed by 4-plex qPCR for the presence of P. falciparum by pfcytb to confirm DNA quality and quantity by amplification of the single copy gene pfβtub and then for deletion of pfhrp2 and pfhrp3. pfcytb, P. falciparum cytochrome b; pfβtub, P. falciparum β-tubulin; pfhrp, P. falciparum histidine-rich protein; qPCR, quantitative PCR.

Figure. pfhrp2 and pfhrp3 deletion frequency in genomic deletion of PfHRP2 and PfHRP3 antigens in Plasmodium falciparum strains, Ethiopia, 2009. P. falciparum–positive samples from 89 persons, previously identified by species-specific PCR were analyzed by 4-plex qPCR for the presence of P. falciparum by pfcytb to confirm DNA quality and quantity by amplification of the single copy gene pfβtub and then for deletion of pfhrp2 and pfhrp3. pfcytb, P. falciparum cytochrome b; pfβtub, P. falciparum β-tubulin; pfhrp, P. falciparum histidine-rich protein; qPCR, quantitative PCR.

Main Article

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