Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 7—July 2025

Research Letter

Genomic Deletion of PfHRP2 and PfHRP3 Antigens in Plasmodium falciparum Strains, Ethiopia, 2009

Tamirat Gebru Woldearegai, Tina Krüger, Sindew Mekasha Feleke, Hassen Mamo, Tesfaye Gelanew, Vanessa Krohmer, Sabine Belard, Peter G. Kremsner, Jana Held, Miriam Rodi, and Andrea KreidenweissComments to Author 
Author affiliation: Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany (T.G. Woldearegai, T. Krüger, V. Krohmer, S. Belard, P.G. Kremsner, J. Held, M. Rodi, A. Kreidenweiss); German Center for Infection Research, partner site Tübingen, Tübingen (T.G. Woldearegai, S. Belard, P.G. Kremsner, J. Held, A. Kreidenweiss); La Trobe University, Melbourne, Victoria, Australia (S.M. Feleke); Ethiopian Public Health Institute, Addis Ababa, Ethiopia (S.M. Feleke); College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa (S.M. Feleke, H. Mamo); Armauer Hansen Research Institute, Addis Ababa (T. Gelanew); Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon (P.G. Kremsner, J. Held, A. Kreidenweiss)

Main Article

Table

Study population and pfhrp2 and pfhrp3 deletion outcomes per study region in genomic deletion of PfHRP2 and PfHRP3 antigens in Plasmodium falciparum strains, Ethiopia, 2009*

Study sites No. samples analyzed Patient median age, y (range) Patient sex, %
 pfcytb+/pfβtub+, no. pfhrp2+/pfhrp3−, no. (%)† pfhrp2−/pfhrp3+, no. (%)† pfhrp2−/pfhrp3−, no. (%)†
F M
Jimma 66 18 (1–73) 46 54 63 19 (30.2) 0 (0) 2 (3.2)
Harar 23 25 (6–60) 30 70 11 2 (18.2) 0 (0) 0 (0)
Total 89 21 (1–73) 38 62 74 21 (28.4) 0 (0) 2 (2.7)

*pfβtub, P. falciparum β-tubulin; pfcytb: P. falciparum cytochrome b; PfHRP, P. falciparum histidine-rich protein. †Percentages were calculated by using the total number of eligible samples (pfcytb+/pfbtub+) from each site as denominator.

Main Article

Page created: May 05, 2025
Page updated: May 28, 2025
Page reviewed: May 28, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external