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Volume 31, Number 7—July 2025

Research

Persistence of SARS-CoV-2 Alpha Variant in White-Tailed Deer, Ohio, USA

Natalie N. Tarbuck1, Sofya K. Garushyants1, Dillon S. McBride, Patricia M. Dennis, John Franks, Karlie Woodard, Austin Shamblin, Michael G. Sovic, Derek T. Collins, Kyle Van Why, Richard J. Webby, Martha I. Nelson, and Andrew S. BowmanComments to Author 
Author affiliation: The Ohio State University, Columbus, Ohio, USA (N.N. Tarbuck, D.S. McBride, P.M. Dennis, A. Shamblin, M.G. Sovic, A.S. Bowman); National Institutes of Health, Bethesda, Maryland, USA (S.K. Garushyants, M.I. Nelson); Cleveland Metroparks Zoo, Cleveland, Ohio, USA (P.M. Dennis); St. Jude Children's Research Hospital, Memphis, Tennessee, USA (J. Franks, K. Woodard, R.J. Webby); Animal and Plant Health Inspection Service, Fort Collins, Colorado, USA (D.T. Collins); Animal and Plant Health Inspection Service, Harrisburg, Pennsylvania, USA (K. Van Why).

Main Article

Figure 4

Mutations in the spike glycoprotein of SARS-CoV-2 viruses circulating in white-tailed deer in northeast Ohio, USA. SARS-CoV-2 spike glycoprotein structure obtained from the Protein Data Base (identification no. 7jji; https://www.rcsb.org). RBD and NTD are labeled. Circles indicate the location of mutations in the SARS-CoV-2 clade B.1.1.7 viruses collected from white-tailed deer in Ohio and other US states: red, L18F; orange, T22I; pink, A982S. Mutation S12F (located in NTD) is not shown because it is located at the flexible N terminus, for which a 3D structure is not available. NTD, N-terminal domain; RBD, receptor-binding domain.

Figure 4. Mutations in the spike glycoprotein of SARS-CoV-2 viruses circulating in white-tailed deer in northeast Ohio, USA. SARS-CoV-2 spike glycoprotein structure obtained from the Protein Data Base (identification no. 7jji; https://www.rcsb.org). RBD and NTD are labeled. Circles indicate the location of mutations in the SARS-CoV-2 clade B.1.1.7 viruses collected from white-tailed deer in Ohio and other US states: red, L18F; orange, T22I; pink, A982S. Mutation S12F (located in NTD) is not shown because it is located at the flexible N terminus, for which a 3D structure is not available. NTD, N-terminal domain; RBD, receptor-binding domain.

Main Article

1These authors contributed equally to this article.

Page created: May 13, 2025
Page updated: June 25, 2025
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