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Volume 31, Number 8—August 2025

Research Letter

Emergence of Novel Fluoroquinolone Resistance Mutations in Mycoplasma bovis, China, 2008–2023

Shimei Lan, Shuang Liu, Wenjing Cui, Zhangcheng Li, Huafang Hao, Ahmed Adel Baz, Jinjia Liang, Xiangrui Jin, Xinmin Yan, Pengcheng Gao, Fuying Zheng, Shengli Chen1Comments to Author , and Yuefeng Chu1Comments to Author 
Author affiliation: State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China (S. Lan, S. Liu, W. Cui, Z. Li, H. Hao, A.A. Baz, J. Liang, X. Jin, X. Yan, P. Gao, F. Zheng, S. Chen, Y. Chu); Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou (S. Lan, S. Liu, Z. Li, H. Hao, A.A. Baz, J. Liang, X. Jin, X. Yan, P. Gao, F. Zheng, S. Chen, Y. Chu); Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agricultural and Rural Affairs, Lanzhou (S. Lan, S. Liu, Z. Li, H. Hao, A.A. Baz, J. Liang, X. Jin, X. Yan, P. Gao, F. Zheng, S. Chen, Y. Chu)

Main Article

Figure 2

Amino acid sequence alignments of quinolone resistance-determining regions of Mycoplasma bovis isolates from China, 2008–2023. Multiple alignments of conserved GyrA (A) and ParC (B) protein sequences for M. bovis ParC protein–ciprofloxacin complex are shown. Escherichia coli K12 and M. bovis PG45 strains were used as controls. Red arrows and black rectangular borders indicate amino acid mutation sites.

Figure 2. Amino acid sequence alignments of quinolone resistance-determining regions of Mycoplasma bovis isolates from China, 2008–2023. Multiple alignments of conserved GyrA (A) and ParC (B) protein sequences for M. bovis ParC protein–ciprofloxacin complex are shown. Escherichia coli K12 and M. bovis PG45 strains were used as controls. Red arrows and black rectangular borders indicate amino acid mutation sites.

Main Article

1These senior authors contributed equally to this article.

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