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Volume 31, Number 9—September 2025

Research

Sporothrix brasiliensis Treatment Failure without Initial Elevated Itraconazole MICs in Felids at Border of Brazil

Carolina Melchior do Prado1, Bram Spruijtenburg1, Emanuel Razzolini, Luciana Chiyo, Carlos Santi, Caroline Amaral Martins, Gabriela Santacruz, Nancy Segovia, José Pereira Brunelli, Regielly Caroline Raimundo Cognialli, Jacques F. Meis, Vânia Aparecida Vicente, Theun de Groot, Eelco F.J. Meijer2, and Flávio Queiroz-Telles2Comments to Author 
Author affiliation: Radboudumc–CWZ Center of Expertise for Mycology, Nijmegen, the Netherlands (C.M. do Prado, B. Spruijtenburg, J.F. Meis, T. de Groot, E.F.J. Meijer); Federal University of Paraná, Curitiba, Brazil (C.M. do Prado, E. Razzolini, R.C.R. Cognialli, V.A. Vicente, F. Queiroz-Telles); Canisius-Wilhelmina Hospital (CWZ)/Dicoon, Nijmegen (B. Spruijtenburg, T. de Groot, E.F.J. Meijer); Zoonosis Control Center, Foz do Iguaçu, Brazil (L. Chiyo, C. Santi, C.A. Martins); National University of the East, Minga Guazú, Paraguay (G. Santacruz, N. Segovia); Ministry of Public Health and Social Welfare, Asuncion, Paraguay (J.P. Brunelli); Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Excellence Center for Medical Mycology, University of Cologne, Cologne, Germany (J.F. Meis)

Main Article

Table 4

Treatment regimen and duration among 50 clinically cured cats and 40 that died from sporotrichosis according to clinical form of disease in study of Sporothrix brasiliensis treatment failure without initial elevated itraconazole MICs in felids at border of Brazil

Sporotrichosis treatment Duration No. cats
Clinically cured Died
Cutaneous disseminated disease, n = 56
No treatment applied Not applicable 0 12
Itraconazole + potassium iodide 1–4 wk 0 12
Itraconazole + potassium iodide 2–7 mo 3 16
Itraconazole + potassium iodide 8–12 mo 11 0
Itraconazole + potassium iodide
 13–15 mo
 2
 0
Fixed cutaneous disease, n = 29
Itraconazole 2–6 mo 12 0
Itraconazole
 7–12 mo
 17
 0
Extracutaneous disease, n = 5
Itraconazole + potassium iodide 2–6 mo 5 0

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: June 23, 2025
Page updated: August 26, 2025
Page reviewed: August 26, 2025
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