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Volume 31, Number 9—September 2025

Research

Sporothrix brasiliensis Treatment Failure without Initial Elevated Itraconazole MICs in Felids at Border of Brazil

Carolina Melchior do Prado1, Bram Spruijtenburg1, Emanuel Razzolini, Luciana Chiyo, Carlos Santi, Caroline Amaral Martins, Gabriela Santacruz, Nancy Segovia, José Pereira Brunelli, Regielly Caroline Raimundo Cognialli, Jacques F. Meis, Vânia Aparecida Vicente, Theun de Groot, Eelco F.J. Meijer2, and Flávio Queiroz-Telles2Comments to Author 
Author affiliation: Radboudumc–CWZ Center of Expertise for Mycology, Nijmegen, the Netherlands (C.M. do Prado, B. Spruijtenburg, J.F. Meis, T. de Groot, E.F.J. Meijer); Federal University of Paraná, Curitiba, Brazil (C.M. do Prado, E. Razzolini, R.C.R. Cognialli, V.A. Vicente, F. Queiroz-Telles); Canisius-Wilhelmina Hospital (CWZ)/Dicoon, Nijmegen (B. Spruijtenburg, T. de Groot, E.F.J. Meijer); Zoonosis Control Center, Foz do Iguaçu, Brazil (L. Chiyo, C. Santi, C.A. Martins); National University of the East, Minga Guazú, Paraguay (G. Santacruz, N. Segovia); Ministry of Public Health and Social Welfare, Asuncion, Paraguay (J.P. Brunelli); Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Excellence Center for Medical Mycology, University of Cologne, Cologne, Germany (J.F. Meis)

Main Article

Table 2

Characteristics of cats tested in study of Sporothrix brasiliensis treatment failure without initial elevated itraconazole MICs in felids at border of Brazil

Characteristic No. (%) cats
Sporotrichosis No sporotrichosis
Total no.
 108
 25
Sex
M 80 (74) 17 (68)
F
 28 (26)
 8 (32)
Age, mo.
<12 13 (12) 3 (12)
>12
 95 (88)
 22 (88)
Castration status
Uncastrated 81 (75) 12 (48)
Castrated 23 (21) 12 (48)
Unknown
 4 (4)
 1 (4)
Vaccination status
Never vaccinated 64 (59) 14 (56)
Full vaccination 11 (10) 4 (16)
Only primary 12 (11) 3 (12)
Occasional 4 (4) 3 (12)
Unknown
 17 (16)
 1 (4)
Access to veterinary care
No access 76 (70) 22 (88)
With access
 32 (30)
 3 (12)
Ownership
With an owner 95 (88) 24 (96)
Stray cat 13 (12) 1 (4)

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: June 23, 2025
Page updated: August 26, 2025
Page reviewed: August 26, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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