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Volume 31, Number 9—September 2025

CME ACTIVITY - Research

Severe Group A Streptococcus Infection among Children, France, 2022–2024

Montserrat Sierra ColominaComments to Author , Alix Flamant, Guillaume Le Balle, Jérémie F. Cohen, Lionel Berthomieu, Stéphane Leteurtre, Yves Gillet, Etienne Javouhey, Stéphane Bechet, Corinne Levy, Robert Cohen, Agnès Ferroni, Damien Dubois, Miguel Angel Hernandez Martinez, Céline Plainvert, Asmaa Tazi, Camille Brehin, and ISAI Study Group,1
Author affiliation: CHU Toulouse, Toulouse, France (M. Sierra Colomina, G. Le Balle, L. Berthomieu, D. Dubois, C. Brehin); Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France (A. Flamant, J.F. Cohen, A. Ferroni); Lille University, CHU Lille, Lille, France (S. Leteurtre); Groupe Francophone de Réanimation et Urgences Pédiatriques, Lille (S. Leteurtre); CHU Lyon, Lyon, France (Y. Gillet, E. Javouhey); Association Clinique et Thérapeutique du Val de Marne, Créteil, France (S. Bechet, C. Levy); Groupe de Pathologie Infectieuse Pédiatrique, Créteil (R. Cohen); National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, Paris Centre, Hôpital Cochin, Paris (M.A. Hernandez Martinez, C. Plainvert, A. Tazi)

Main Article

Table 1

Clinical features of severe group A Streptococcus infections among 402 children, France, 2022–2024*

Clinical features Value
Median age (IQR), y
 4 (2–7.5)
Sex
M 234 (58)
F
 168 (42)
Comorbidities 52 (13)
Immunosuppression
 7 (2)
Viral infection in the previous 15 d 109 (27)
Influenza 28/112 (25)
Respiratory syncytial virus 7/112 (6)
Chicken pox 37/112 (33)
SARS-CoV-2 5/112 (4)
Other
 37/112 (33)
Isolated case 326 (81)
Isolated fever
 18 (4)
Site of infection
Multiple 146 (36)
Ear-nose-throat 135 (34)
Skin and soft tissue 63 (16)
Bone and joint 57 (14)
Lower respiratory 84 (21)
Pleuro-pneumonia 69 (17)
Others†
 34 (8)
Septic shock‡ 34 (8)
Toxic rash 37 (9)

*Values are no. (%) except as indicated. †Meningitis, endocarditis, peritonitis, dental cellulitis. ‡Defined as persistence of several organ failures or acute circulatory failure, failure to correct arterial hypotension despite vascular filling of >40 mL/kg, or both.

Main Article

1Additional members who contributed data are listed at the end of this article.

Page created: July 11, 2025
Page updated: August 21, 2025
Page reviewed: August 21, 2025
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