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Volume 31, Number 9—September 2025

CME ACTIVITY - Research

Severe Group A Streptococcus Infection among Children, France, 2022–2024

Montserrat Sierra ColominaComments to Author , Alix Flamant, Guillaume Le Balle, Jérémie F. Cohen, Lionel Berthomieu, Stéphane Leteurtre, Yves Gillet, Etienne Javouhey, Stéphane Bechet, Corinne Levy, Robert Cohen, Agnès Ferroni, Damien Dubois, Miguel Angel Hernandez Martinez, Céline Plainvert, Asmaa Tazi, Camille Brehin, and ISAI Study Group,1
Author affiliation: CHU Toulouse, Toulouse, France (M. Sierra Colomina, G. Le Balle, L. Berthomieu, D. Dubois, C. Brehin); Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France (A. Flamant, J.F. Cohen, A. Ferroni); Lille University, CHU Lille, Lille, France (S. Leteurtre); Groupe Francophone de Réanimation et Urgences Pédiatriques, Lille (S. Leteurtre); CHU Lyon, Lyon, France (Y. Gillet, E. Javouhey); Association Clinique et Thérapeutique du Val de Marne, Créteil, France (S. Bechet, C. Levy); Groupe de Pathologie Infectieuse Pédiatrique, Créteil (R. Cohen); National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, Paris Centre, Hôpital Cochin, Paris (M.A. Hernandez Martinez, C. Plainvert, A. Tazi)

Main Article

Table 2

Management of severe group A Streptococcus infections among 402 children, France, 2022–2024

Treatment No. (%)
Oxygen therapy 120 (30)
Conventional 45 (11)
High-flow 27 (7)
Noninvasive ventilation 11 (3)
Invasive ventilation 32 (8)
Extracorporeal membrane oxygenation
 5 (1)
Hemodynamic therapy 97 (24)
Fluid resuscitation 97 (24)
Vasopressor treatment
 50 (12)
First-line antibiotic treatment
Amoxicillin/clavulanate 138 (34)
Third generation cephalosporin 141 (35)
β-lactam + clindamycin
 173 (43)
Adjunctive therapies
Intravenous Immunoglobulins 17 (4)
Hydrocortisone hemisuccinate for shock 19 (4)

Main Article

1Additional members who contributed data are listed at the end of this article.

Page created: July 11, 2025
Page updated: August 21, 2025
Page reviewed: August 21, 2025
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