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Volume 31, Number 9—September 2025

CME ACTIVITY - Research

Severe Group A Streptococcus Infection among Children, France, 2022–2024

Montserrat Sierra ColominaComments to Author , Alix Flamant, Guillaume Le Balle, Jérémie F. Cohen, Lionel Berthomieu, Stéphane Leteurtre, Yves Gillet, Etienne Javouhey, Stéphane Bechet, Corinne Levy, Robert Cohen, Agnès Ferroni, Damien Dubois, Miguel Angel Hernandez Martinez, Céline Plainvert, Asmaa Tazi, Camille Brehin, and ISAI Study Group,1
Author affiliation: CHU Toulouse, Toulouse, France (M. Sierra Colomina, G. Le Balle, L. Berthomieu, D. Dubois, C. Brehin); Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France (A. Flamant, J.F. Cohen, A. Ferroni); Lille University, CHU Lille, Lille, France (S. Leteurtre); Groupe Francophone de Réanimation et Urgences Pédiatriques, Lille (S. Leteurtre); CHU Lyon, Lyon, France (Y. Gillet, E. Javouhey); Association Clinique et Thérapeutique du Val de Marne, Créteil, France (S. Bechet, C. Levy); Groupe de Pathologie Infectieuse Pédiatrique, Créteil (R. Cohen); National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, Paris Centre, Hôpital Cochin, Paris (M.A. Hernandez Martinez, C. Plainvert, A. Tazi)

Main Article

Table 3

Molecular characterization of 149 Streptococcus pyogenes isolates analyzed at the French National Reference Center for Streptococci in study of children with severe group A Streptococcus infections, France, 2022–2024

Variable No. (%)
Superantigen genes 148
SpeA 110 (74.3)
SpeB 148 (100)
SpeC 76 (51.3)
SmeZ 146 (98.6)
Sic* 108 (73.0)
ssa
 11 (7.4)
emm genotypes 148
emm1 108 (73.0)
emm4 4 (2.7)
emm12 16 (10.8)
emm77 4 (2.7)
emm87 4 (2.7)
emm89 4 (2.7)
Others† 8 (5.4)
Not done
 1
Whole-genome sequencing 25
emm1 20
M1UK clone among emm1 strains 10

*Sic-like genes were not analyzed. †Others: 1 strain of each of emm2, emm3, emm11, emm22, emm44, emm75, emm169, and emm209.

Main Article

1Additional members who contributed data are listed at the end of this article.

Page created: July 11, 2025
Page updated: August 21, 2025
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