Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Volume 31, Number 9—September 2025

Dispatch

Novel Henipavirus, Salt Gully Virus, Isolated from Pteropid Bats, Australia

Jennifer BarrComments to Author , Sarah Caruso, Sarah J. Edwards, Shawn Todd, Ina Smith, Mary Tachedjian, Gary Crameri, Lin-Fa Wang, and Glenn A. Marsh
Author affiliation: Author affiliations: Commonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Geelong, Victoria, Australia (J. Barr, S. Caruso, S.J. Edwards, S. Todd, I. Smith, M. Tachedjian, G. Crameri, G.A. Marsh); Duke University-National University of Singapore Medical School, Singapore (L-F. Wang)

Main Article

Figure 3

Ephrin-B2 and ephrin-B3 host cell receptor usage from a study investigating a novel henipavirus, Salt Gully virus (SGV), isolated from pteropid bats, Australia. Three cell lines—HeLa-USU, recombinant HeLa-USU expressing ephrin-B2, and HeLa-USU expressing ephrin-B3—were inoculated with SGV and observed daily for viral cytopathic effects (CPE). CPE was seen in all 3 cell lines by 5 dpi, indicating that SGV does not use ephrin-B2 or ephrin-B3 as a host cell receptor. A) Uninfected HeLa-USU cells; B) uninfected HeLa-USU cells expressing ephrin-B2; C) uninfected HeLa-USU cells expressing ephrin-B3; D) SGV-infected HeLa-USU cells; E) SGV-infected HeLa-USU ephrin-B2 cells; and F) SGV-infected HeLa-USU ephrin-B3 cells. Scale bars indicate 400um.

Figure 3. Ephrin-B2 and ephrin-B3 host cell receptor usage from a study investigating a novel henipavirus, Salt Gully virus (SGV), isolated from pteropid bats, Australia. Three cell lines—HeLa-USU, recombinant HeLa-USU expressing ephrin-B2, and HeLa-USU expressing ephrin-B3—were inoculated with SGV and observed daily for viral cytopathic effects (CPE). CPE was seen in all 3 cell lines by 5 dpi, indicating that SGV does not use ephrin-B2 or ephrin-B3 as a host cell receptor. A) Uninfected HeLa-USU cells; B) uninfected HeLa-USU cells expressing ephrin-B2; C) uninfected HeLa-USU cells expressing ephrin-B3; D) SGV-infected HeLa-USU cells; E) SGV-infected HeLa-USU ephrin-B2 cells; and F) SGV-infected HeLa-USU ephrin-B3 cells. Scale bars indicate 400um.

Main Article

Page created: August 06, 2025
Page updated: August 26, 2025
Page reviewed: August 26, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external