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Volume 31, Number 9—September 2025

Dispatch

Novel Henipavirus, Salt Gully Virus, Isolated from Pteropid Bats, Australia

Jennifer BarrComments to Author , Sarah Caruso, Sarah J. Edwards, Shawn Todd, Ina Smith, Mary Tachedjian, Gary Crameri, Lin-Fa Wang, and Glenn A. Marsh
Author affiliation: Author affiliations: Commonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Geelong, Victoria, Australia (J. Barr, S. Caruso, S.J. Edwards, S. Todd, I. Smith, M. Tachedjian, G. Crameri, G.A. Marsh); Duke University-National University of Singapore Medical School, Singapore (L-F. Wang)

Main Article

Figure 3

Ephrin-B2 and ephrin-B3 host cell receptor usage from a study investigating a novel henipavirus, Salt Gully virus (SGV), isolated from pteropid bats, Australia. Three cell lines—HeLa-USU, recombinant HeLa-USU expressing ephrin-B2, and HeLa-USU expressing ephrin-B3—were inoculated with SGV and observed daily for viral cytopathic effects (CPE). CPE was seen in all 3 cell lines by 5 dpi, indicating that SGV does not use ephrin-B2 or ephrin-B3 as a host cell receptor. A) Uninfected HeLa-USU cells; B) uninfected HeLa-USU cells expressing ephrin-B2; C) uninfected HeLa-USU cells expressing ephrin-B3; D) SGV-infected HeLa-USU cells; E) SGV-infected HeLa-USU ephrin-B2 cells; and F) SGV-infected HeLa-USU ephrin-B3 cells. Scale bars indicate 400um.

Figure 3. Ephrin-B2 and ephrin-B3 host cell receptor usage from a study investigating a novel henipavirus, Salt Gully virus (SGV), isolated from pteropid bats, Australia. Three cell lines—HeLa-USU, recombinant HeLa-USU expressing ephrin-B2, and HeLa-USU expressing ephrin-B3—were inoculated with SGV and observed daily for viral cytopathic effects (CPE). CPE was seen in all 3 cell lines by 5 dpi, indicating that SGV does not use ephrin-B2 or ephrin-B3 as a host cell receptor. A) Uninfected HeLa-USU cells; B) uninfected HeLa-USU cells expressing ephrin-B2; C) uninfected HeLa-USU cells expressing ephrin-B3; D) SGV-infected HeLa-USU cells; E) SGV-infected HeLa-USU ephrin-B2 cells; and F) SGV-infected HeLa-USU ephrin-B3 cells. Scale bars indicate 400um.

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Page created: August 06, 2025
Page updated: August 19, 2025
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