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Volume 32, Number 1—January 2026

Dispatch

Disseminated Nocardia ignorata Infection with Splenic and Brain Involvement in Patient with Large B-Cell Lymphoma

Sherif Elbaz, Mahmoud IsmailComments to Author , Seth Glassman, Asmaa Badr, and Eric John Dove
Author affiliation: University at Buffalo, Buffalo, New York, USA (S. Elbaz, M. Ismail, S. Glassman, E.J. Dove); The Ohio State University, Columbus, Ohio, USA (A. Badr)

Main Article

Figure 2

Ultrasound-guided biopsy image of spleen of 79-year-old man with chronic obstructive pulmonary disease and large B-cell lymphoma who had disseminated Nocardia ignorata infection, United States. Tissue fragment shows extensive necrosis with a small focus of large B-cell lymphoma. Neoplastic cells stain positively for CD20 antibody, paired box protein 5, and B‑cell lymphoma 2, with 20% expression of myelocytomatosis oncogene, corroborating the diagnosis of disseminated Nocardia ignorata infection. Mindbomb‑1 antibody is positive in 90% of the cells. Acid-fast, Fite–Faraco, Gomori methenamine silver, and periodic acid–Schiff special stains do not demonstrate identifiable microorganisms or microbiota. Original magnification × 20.

Figure 2. Ultrasound-guided biopsy image of spleen of 79-year-old man with chronic obstructive pulmonary disease and large B-cell lymphoma who had disseminated Nocardia ignorata infection, United States. Tissue fragment shows extensive necrosis with a small focus of large B-cell lymphoma. Neoplastic cells stain positively for CD20 antibody, paired box protein 5, and B‑cell lymphoma 2, with 20% expression of myelocytomatosis oncogene, corroborating the diagnosis of disseminated Nocardia ignorata infection. Mindbomb‑1 antibody is positive in 90% of the cells. Acid-fast, Fite–Faraco, Gomori methenamine silver, and periodic acid–Schiff special stains do not demonstrate identifiable microorganisms or microbiota. Original magnification × 20.

Main Article

Page created: December 31, 2025
Page updated: January 29, 2026
Page reviewed: January 29, 2026
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