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Volume 32, Number 10—October 2026

Dispatch

Comparison of Baloxavir-Based Combinations and Monotherapies for Treating Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Mice

Seong Cheol Min, Ju Ryeong Lee, Beom Kyu Kim, Ji-Hyun Park, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Santosh Chokkakula, Aman Jain, Young Ki Choi, Yun Hee Baek, and Min-Suk SongComments to Author 
Author affiliation: Chungbuk National University College of Medicine, Chungbuk, South Korea (S.C. Min, J.R. Lee, B.K. Kim, J.-H. Park, D.G. Lee, G.C. Lee, S.H. An, S. Chokkakula, A. Jain, Y.H. Baek, M.-S. Song); Korea Virus Research Institute Yuseong-gu, Daejeon, South Korea (Y.K. Choi)

Main Article

Figure 2

Lung and brain histopathology and influenza A nucleoprotein immunoreactivity at 6 dpi after monotherapy or combination therapy in a study of treating influenza A(H5N1) clade 2.3.4.4b virus infection in mice. A) Brain sections; B) lung sections. Sections from vehicle, OSP, MPV, BXA, OSP/MPV, BXA/OSP, and BXA/MPV groups. For each group, representative hematoxylin and eosin images (left) and immunohistochemistry for influenza A nucleoprotein (right; 3,3′-diaminobenzidine with hematoxylin counterstain) are shown as whole-section views with corresponding higher-magnification insets (boxed regions). Scale bars indicate 1.25 mm for whole-section views; and 100 μm for higher-magnification insets. BXA, baloxavir acid; MPV, molnupiravir; OSP, oseltamivir phosphate.

Figure 2. Lung and brain histopathology and influenza A nucleoprotein immunoreactivity at 6 dpi after monotherapy or combination therapy in a study of treating influenza A(H5N1) clade 2.3.4.4b virus infection in mice. A) Brain sections; B) lung sections. Sections from vehicle, OSP, MPV, BXA, OSP/MPV, BXA/OSP, and BXA/MPV groups. For each group, representative hematoxylin and eosin images (left) and immunohistochemistry for influenza A nucleoprotein (right; 3,3′-diaminobenzidine with hematoxylin counterstain) are shown as whole-section views with corresponding higher-magnification insets (boxed regions). Scale bars indicate 1.25 mm for whole-section views; and 100 μm for higher-magnification insets. BXA, baloxavir acid; MPV, molnupiravir; OSP, oseltamivir phosphate.

Main Article

Page created: September 05, 2026
Page updated: September 22, 2026
Page reviewed: September 22, 2026
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