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Volume 32, Number 2—February 2026

Dispatch

Genomic Analysis of Doxycycline Resistance–Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum

George S. Long, Mackenzie Neale, Thomas Braukmann, Vanessa Tran, Nishant Singh, Vanessa Allen, Muhammad Morshed, Jessica Minion, Paul Van Caeseele, Maud Vallée, Todd Hatchette, Samir N. Patel, Raymond S.W. Tsang, and Venkata R. DuvvuriComments to Author 
Author affiliation: Public Health Ontario, Toronto, Ontario, Canada (G.S. Long, T. Braukmann, V. Tran, N. Singh, V. Allen, S.N. Patel, V.R. Duvvuri); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (M. Neale, R.S.W. Tsang); University of Toronto, Toronto (T. Braukmann, V. Tran, V. Allen, S.N. Patel, V.R. Duvvuri); Sinai Health and University Health Network, Toronto (V. Allen); British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada (M. Morshed); University of British Columbia, Vancouver (M. Morshed); Roy Romanow Provincial Laboratory, Regina, Saskatchewan, Canada (J. Minion); University of Saskatchewan, Regina (J. Minion); Cadham Provincial Laboratory, Winnipeg (P. Van Caeseele); University of Manitoba, Winnipeg (P. Van Caeseele); Laboratoire de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada (M. Vallée); Dalhousie University, Halifax, Nova Scotia, Canada (T. Hatchette); York University, Toronto (V.R. Duvvuri)

Main Article

Table 4

Geographic and genomic details of Treponema pallidum subsp. pallidum strains with a mutation at doxycycline-associated 16S rRNA site 968 used in genomic analysis of doxycycline resistance–associated 16S rRNA mutations in T. pallidum subsp. pallidum*

NCBI Sequence Read Archive accession no. Lineage Collection date Country 16S rRNA: 968
ERR7123576 Nichols Unknown Unknown G/T
ERR3684613 SS14 2013 United Kingdom G/T
ERR3684456 SS14 2016 United Kingdom G/T
ERR4045387 SS14 2016 United Kingdom G/T
ERR3684510 SS14 2016 United Kingdom G/T
ERR3684626 SS14 2016 United Kingdom G/T
ERR3684512 SS14 2017 United Kingdom G/T
ERR5210563 Nichols 2018 Hungary G/T
ERR5210581 SS14 2019 Australia G/T

*G/T indicates a heterozygous allele. NCBI, National Center for Biotechnology Information.

Main Article

Page created: January 16, 2026
Page updated: February 19, 2026
Page reviewed: February 19, 2026
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