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Volume 32, Number 4—April 2026

Research

Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025

Justine de Larminat, Kevin La, Philippe Bidet, André Birgy, Sandrine Liguori, Pierre Phlipaux, Celine Courroux, Florence Crombé, Jorge Blanco, Paul Coppo, Antoine Dossier, Laurence Armand-Lefevre, François Xavier Weill, Carolina Silva Nodari, Gabrielle Jones, Aurelie Cointe, and Stéphane BonacorsiComments to Author 
Author affiliation: Escherichia coli National Reference Center, Robert-Debré University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France (J. de Larminat, K. La, P. Bidet, A. Birgy, S. Liguori, P. Phlipaux, C. Courroux, A. Cointe, S. Bonacorsi); Infection, Antimicrobien, Modélisation, Évolution, INSERM, Université Paris Cité, Paris (J. de Larminat, K. La, P. Bidet, A. Birgy, L. Armand-Lefevre, A. Cointe, S. Bonacorsi); Universitair Ziekenhuis Brussel, Brussels, Belgium (F. Crombé); Vrije Universiteit Brussel–Campus Jette, Brussels (F. Crombé); University of Santiago de Compostela, Lugo, Spain (J. Blanco); Hôpital Saint-Antoine, Paris (P. Coppo); Sorbonne Université, Paris (P. Coppo); Hôpital Bichat–Claude-Bernard, APHP, Paris (A. Dossier, L. Armand-Lefevre); Université Paris Diderot UFR de Médecine Site Xavier-Bichat, Paris (L. Armand-Lefevre); Institut Pasteur, Université Paris Cité, Paris (F.X. Weill, C. Silva Nodari); Santé Publique France, Saint-Maurice, France (G. Jones)

Main Article

Figure 1

Unrooted phylogenetic tree based on core genome alignment of 51 Shiga toxin–producing Escherichia coli isolates from study of hemolytic uremic syndrome outbreak in adults and Shiga toxin–producing Escherichia coli negative for locus of enterocyte effacement, France, 2025. Shown are the France 2025 outbreak strain (HC5 326896, in purple) and other strains with the same core-genome multilocus sequence typing HC200 2073 group identified in EnteroBase and GenBank (Appendix Table 1). Isolates are divided into 2 main groups, A and B, in accordance with their phylogenetic distribution. Only HC5 comprising >2 genomes are colored. Figures 1–3 are combined in Appendix Figure 1.

Figure 1. Unrooted phylogenetic tree based on core genome alignment of 51 Shiga toxin–producing Escherichia coli isolates from study of hemolytic uremic syndrome outbreak in adults and Shiga toxin–producing Escherichia coli negative for locus of enterocyte effacement, France, 2025. Shown are the France 2025 outbreak strain (HC5 326896, in purple) and other strains with the same core-genome multilocus sequence typing HC200 2073 group identified in EnteroBase and GenBank (Appendix Table 1). Isolates are divided into 2 main groups, A and B, in accordance with their phylogenetic distribution. Only HC5 comprising >2 genomes are colored. Figures 1–3 are combined in Appendix Figure 1.

Main Article

Page created: February 27, 2026
Page updated: April 15, 2026
Page reviewed: April 15, 2026
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