Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025
Justine de Larminat, Kevin La, Philippe Bidet, André Birgy, Sandrine Liguori, Pierre Phlipaux, Celine Courroux, Florence Crombé, Jorge Blanco, Paul Coppo, Antoine Dossier, Laurence Armand-Lefevre, François Xavier Weill, Carolina Silva Nodari, Gabrielle Jones, Aurelie Cointe, and Stéphane Bonacorsi
Author affiliation: Escherichia coli National Reference Center, Robert-Debré University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France (J. de Larminat, K. La, P. Bidet, A. Birgy, S. Liguori, P. Phlipaux, C. Courroux, A. Cointe, S. Bonacorsi); Infection, Antimicrobien, Modélisation, Évolution, INSERM, Université Paris Cité, Paris (J. de Larminat, K. La, P. Bidet, A. Birgy, L. Armand-Lefevre, A. Cointe, S. Bonacorsi); Universitair Ziekenhuis Brussel, Brussels, Belgium (F. Crombé); Vrije Universiteit Brussel–Campus Jette, Brussels (F. Crombé); University of Santiago de Compostela, Lugo, Spain (J. Blanco); Hôpital Saint-Antoine, Paris (P. Coppo); Sorbonne Université, Paris (P. Coppo); Hôpital Bichat–Claude-Bernard, APHP, Paris (A. Dossier, L. Armand-Lefevre); Université Paris Diderot UFR de Médecine Site Xavier-Bichat, Paris (L. Armand-Lefevre); Institut Pasteur, Université Paris Cité, Paris (F.X. Weill, C. Silva Nodari); Santé Publique France, Saint-Maurice, France (G. Jones)
Main Article
Figure 3
Figure 3. Distribution of genes encoding major virulence factors of 51 Shiga toxin–producing Escherichia coli isolates from study of hemolytic uremic syndrome outbreak in adults and Shiga toxin–producing Escherichia coli negative for locus of enterocyte effacement, France, 2025. Shown are the France 2025 outbreak strain (HC5 326896, in purple) and other strains with the same core-genome multilocus sequence typing HC200 2073 group identified in EnteroBase and GenBank (Appendix Table 1). Heatmap assembled from phylogenic tree using ITOL tool (https://itol.embl.de), based on gene sequences of reference isolate CNREC_004-7. The score represents the combination of percentage coverage and percentage nucleotide identity. Asterisk indicates genes located on the large plasmid (134 kb). Figures 1–3 are combined in Appendix Figure 1.
Main Article
Page created: February 27, 2026
Page updated: April 15, 2026
Page reviewed: April 15, 2026
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.