Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025
Justine de Larminat, Kevin La, Philippe Bidet, André Birgy, Sandrine Liguori, Pierre Phlipaux, Celine Courroux, Florence Crombé, Jorge Blanco, Paul Coppo, Antoine Dossier, Laurence Armand-Lefevre, François Xavier Weill, Carolina Silva Nodari, Gabrielle Jones, Aurelie Cointe, and Stéphane Bonacorsi
Author affiliation: Escherichia coli National Reference Center, Robert-Debré University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France (J. de Larminat, K. La, P. Bidet, A. Birgy, S. Liguori, P. Phlipaux, C. Courroux, A. Cointe, S. Bonacorsi); Infection, Antimicrobien, Modélisation, Évolution, INSERM, Université Paris Cité, Paris (J. de Larminat, K. La, P. Bidet, A. Birgy, L. Armand-Lefevre, A. Cointe, S. Bonacorsi); Universitair Ziekenhuis Brussel, Brussels, Belgium (F. Crombé); Vrije Universiteit Brussel–Campus Jette, Brussels (F. Crombé); University of Santiago de Compostela, Lugo, Spain (J. Blanco); Hôpital Saint-Antoine, Paris (P. Coppo); Sorbonne Université, Paris (P. Coppo); Hôpital Bichat–Claude-Bernard, APHP, Paris (A. Dossier, L. Armand-Lefevre); Université Paris Diderot UFR de Médecine Site Xavier-Bichat, Paris (L. Armand-Lefevre); Institut Pasteur, Université Paris Cité, Paris (F.X. Weill, C. Silva Nodari); Santé Publique France, Saint-Maurice, France (G. Jones)
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Figure 2
Figure 2. Origins and serotypes of 51 Shiga toxin–producing Escherichia coli isolates from study of HUS in adults and Shiga toxin–producing Escherichia coli negative for locus of enterocyte effacement, France, 2025. Shown are the outbreak strain (HC5 326896, in purple) and other strains with the same core-genome multilocus sequence typing HC200 2073 group identified in EnteroBase and GenBank (Appendix Table 1). Only HC5 comprising >2 genomes are colored. Country of origin, year of isolation, source, disease, and O and H serotypes are indicated; O77 g denotes serogroup from the O77 group. Dash indicates the serotype is not available. AUS, Australia; BEL, Belgium; CAN, Canada; FRA, France; HUS, hemolytic uremic syndrome; SCT, Scotland; UK, United Kingdom; USA, United States. Figures 1–3 are combined in Appendix Figure 1.
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