Yellow Fever Virus Surveillance in Callithrix spp. Marmosets during Epizootic Outbreak, Brazil, 2024–2025
Márcio Junio Lima Siconelli, Jéssica Caroline de Almeida Dias, Eduardo Ferreira Machado, Mariana Sequetin Cunha, Natália Coelho Couto de Azevedo Fernandes, Juliana Mariotti Guerra, Luana Bonon, Alline Borges Salomão, Karin Werther, Karina Paes Bürger, Adolorata Aparecida Bianco Carvalho, Daniel Marques, and Benedito Antonio Lopes da Fonseca
Author affiliation: Unidade de Vigilância de Zoonoses da Divisão de Vigilância Ambiental em Saúde, Secretaria Municipal da Saúde, Ribeirão Preto, Brazil (M.J.L. Siconelli); Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto (M.J.L. Siconelli, J.C. de Almeida Dias, B.A. Lopes da Fonseca); Centro de Patologia, Instituto Adolfo Lutz de São Paulo, Secretaria Estadual da Saúde de São Paulo, São Paulo, Brazil (E.F. Machado, N.C.C.A. Fernandes); Centro de Virologia, Instituto Adolfo Lutz de São Paulo, Secretaria Estadual da Saúde de São Paulo, São Paulo (M.S. Cunha); Universidade de São Paulo Departamento de Patologia da Faculdade de Medicina Veterinária e Zootecnia, São Paulo (J.M. Guerra); Programa de Residência em Área Profissional da Saúde, Medicina Veterinária e Saúde, do Departamento de Patologia, Reprodução e Saúde Única da Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil (L. Bonon, A.B. Salomão, K. Werther, K.P. Bürger, A.A.B. Carvalho); Grupo de Vigilância Epidemiológica, Centro de Vigilância Epidemiológica “Prof. Alexandre Vranjac,” Secretaria Estadual da Saúde de São Paulo, São Paulo (D. Marques)
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Figure 3
Figure 3. Laboratory analysis of organ samples collected from Callithrix penicillata marmosets with severe hepatic lesions due to yellow fever during epizootic yellow fever outbreak, Brazil, 2024–2025. A) Hematoxylin and eosin stain of liver showing acute and severe hepatic damage characterized by diffuse macrovesicular steatosis and focal hemorrhage (star). Original magnification ×10. B) Hematoxylin and eosin stain of liver showing acute and severe hepatic damage with macrovesicular steatosis (black arrowhead), focal hemorrhage (star), and a Councilman–Rocha Lima body (elongated arrow). Original magnification ×20. C) Immunohistochemisty stain showing hepatocytes positive for yellow fever virus antigen (brown staining). Original magnification ×20. D) Immunohistochemistry stain of renal tubular epithelial cells; brown stained cells are positive for yellow fever virus antigen. Original magnification ×10.
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Page updated: June 01, 2026
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