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Volume 32, Number 7—July 2026

Research

Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA

Ran Zhuo1, Colette J. Matysiak Match1, Sanchi Malhotra, Huan Vinh Dong, Kristina Adachi, Robert S. Venick, Grace Aldrovandi, and Shangxin YangComments to Author 
Author affiliation: University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA (R. Zhuo, C.J. Matysiak Match, S. Malhotra, H.V. Dong, K. Adachi, R.S. Venick, G. Aldrovandi, S. Yang); Duke University School of Medicine, Durham, North Carolina, USA (R. Zhuo); University of California San Francisco School of Medicine, San Francisco, California, USA (C.J.M. Match)

Main Article

Table 2

Genomic analysis for 2 pediatric cases of acute severe hepatitis of unknown etiology associated with AAV2 and HAdV-F41 co-infection, California, USA*

Case no. Source NGS method Virus identified % Genome/ gene coverage % Identity Reference genome/gene GenBank accession no.
Reference isolate Patient isolate
1
 Plasma and liver Shotgun AAV2 81.3 95.4 AAV isolate CHC3511_AAV.FL.circular, complete genome MK163942 SRX33017783
Whole blood
 Amplicon (hexon gene)
 HAdV-F41
 100
 96.7
 HAdV-F41 isolate 2330/N.Nov/RU/2009 hexon gene, partial cds
 HM588740
 SRX33034982
2 Plasma Shotgun AAV2 35.1 90.9 AAV2, complete genome NC_001401 SRX33017784
Whole blood Amplicon (hexon gene) HAdV-F41 86 99.5 HAdV-F41isolate 2330/N.Nov/RU/2009 hexon gene, partial cds HM588740 SRX33034983

*AAV2, adeno-associated virus type 2; HAdV-F41, human adenovirus species F type 41; cds, coding sequence; NGS, next-generation sequencing.

Main Article

1These authors contributed equally to this article.

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Page updated: May 12, 2026
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