Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease: Background, Evolution, and Current Concerns
Paul Brown*

, Robert G. Will†, Raymond Bradley‡, David M. Asher§, and Linda Detwiler¶
Author affiliations: *National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; †National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, Scotland; ‡Central Veterinary Laboratory, New Haw, Addlestone, UK; §Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; ¶Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Robbinsville, New Jersey, USA
Main Article
Table 2
Evolving assessment of criteria used to link bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease
|
Assessment through early 1996 |
Criteria |
Jan 1 |
Feb 1 |
Mar 1 |
Mar 8 |
Mar 20 |
Novel clinical phenotype |
Uncertain |
Possible |
Probable |
Probable |
Probable |
Novel neuropathologic phenotype |
Uncertain |
Possible |
Probable |
Probable |
Probable |
Distinct from pre-1980 cases in UK |
Unknown |
Possible |
Probable |
Probable |
Probable |
No association with PRNP mutations |
Uncertain |
Uncertain |
Uncertain |
Probable |
Probable |
Distinct from cases outside UK |
Unknown |
Unknown |
Unknown |
Possible |
Probable |
Main Article
Page created: March 23, 2011
Page updated: August 07, 2012
Page reviewed: August 07, 2012
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