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Volume 7, Number 1—February 2001

Perspective

Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease: Background, Evolution, and Current Concerns

Paul Brown*Comments to Author , Robert G. Will†, Raymond Bradley‡, David M. Asher§, and Linda Detwiler¶
Author affiliations: *National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; †National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, Scotland; ‡Central Veterinary Laboratory, New Haw, Addlestone, UK; §Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; ¶Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Robbinsville, New Jersey, USA

Main Article

Table 2

Evolving assessment of criteria used to link bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease

Assessment through early 1996
Criteria Jan 1 Feb 1 Mar 1 Mar 8 Mar 20
Novel clinical phenotype Uncertain Possible Probable Probable Probable
Novel neuropathologic phenotype Uncertain Possible Probable Probable Probable
Distinct from pre-1980 cases in UK Unknown Possible Probable Probable Probable
No association with PRNP mutations Uncertain Uncertain Uncertain Probable Probable
Distinct from cases outside UK Unknown Unknown Unknown Possible Probable

Main Article

Page created: March 23, 2011
Page updated: August 07, 2012
Page reviewed: August 07, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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