Volume 7, Number 3—June 2001
Synopsis
Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome
Shahid Husain, Marilyn M. Wagener, and Nina Singh
Table 3
Variables associated with death in organ transplant recipients with Cryptococcus neoformans infection
| Variable (no. of patients for whom data available) | Death (%) | Survival (%) | p value |
|---|---|---|---|
| Age (mean) | 43.6 yrs | 43.4 yrs | NSa |
| Prior rejection (17) | 35 | 65 | NS |
| No rejection (50) | 28 | 72 | |
| Rejection within 6 months of onset of cryptococcosis (3) | 33 | 67 | NS |
| Increased immunosuppression (11) | 46 | 54 | NS |
| Fever (39) | 31 | 69 | NS |
| No fever (21) | 33 | 67 | |
| Renal failure (37) | 43 | 57 | 0.005 |
| No renal failure (18) | 6 | 94 | |
| Mental status | 0.03 | ||
| Abnormal (22) | 54 | 45 | |
| Normal (53) | 28 | 72 | |
| Treatment | NS (0.16) | ||
| AmBb (52) | |||
| AmB + 5 FCc (77) | 48 | 52 | |
| Fluconazole (14) | 38 | 62 | |
| Site involved | 21 | 79 | 0.04d |
| Central nervous system (101) | 49 | 51 | |
| Pulmonary (32) | 22 | 78 | |
| Skin/osteoarticular (28) | 21 | 79 | |
| Type of transplant | NS | ||
| Liver (20) | 40 | 60 | |
| Kidney (139) | 41 | 59 | |
| Heart (10) | 60 | 40 | |
| Lung (3) | 33 | 67 |
aNS = not significant, p >0.05.
bAmB = amphotericin B deoxycholate.
cFC = flucytosine. Dp value represents the difference for CNS versus other sites.
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