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Volume 7, Number 3—June 2001
Synopsis

Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome

Shahid Husain, Marilyn M. Wagener, and Nina SinghComments to Author 
Author affiliations: Veterans Affairs Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA

Main Article

Table 4

Variables associated with death in patients with central nervous system Cryptococcus neoformans infection

 Variable (no. of patients for whom data available) Death (%) Survival (%) p value
Age (mean) 40.6 yrs 42.4 yrs NSa
Fever (29) 34 (10/29) 66 (10/29) NS
No fever (7) 43 (3/7) 57 (4/7)
Headache (20) 25 (5/20) 75 (15/20) NS (.09)
No headache (21) 52 (11/21) 48 (10/21)
Abnormal mental status (20) 55 (11/20) 45 (9/20) NS
Normal mental status (26) 31 (8/26) 69 (18/26)
White blood cell >20/mm3 (20) 40 (8/20) 60 (12/20) NS
White blood cell <20/mm3 (13) 62 (8/13) 38 (5/13)
Cryptococcal antigen titer >1,024 (10) 20 (2/10) 80 (8/10) NS
Cryptococcal antigen titer <1,024 (17) 35 (6/17) 65 (11/17)
Positive blood culture (8) 13 (1/8) 87 (7/8) NS
Negative blood culture (16) 50 (8/16) 50 (8/16)
Renal failure (22) 54 (12/22) 46 (10/22) .011
No renal failure (12) 8 (1/12) 92 (11/12)
Therapy NS
AmBb alone (55) 47 (26/55) 53 (29/55)
AmB + 5 FCc (32) 50 (16/32) 50 (16/32)
Fluconazole (5) 40 (2/5) 60 (3/5)

aNS = not significant, p >0.05.
bAmB = Amphotericin B deoxycholate.
cFC = flucytosine.

Main Article

Page created: April 26, 2012
Page updated: April 26, 2012
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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