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Volume 7, Number 6—December 2001
Research

Advanced Age a Risk Factor for Illness Temporally Associated with Yellow Fever Vaccination

Michael Martin*†, Leisa H. Weld*, Theodore F. Tsai*, Gina T. Mootrey*, Robert T. Chen*, Manette Niu‡, Martin S. Cetron*, and the GeoSentinel Yellow Fever Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;; †Emory School of Medicine, Atlanta, Georgia, USA;; ‡Center for Biologic Evaluation, U.S. Food and Drug Administration, Rockville, Maryland, USA

Main Article

Table 1

Categories of vaccine adverse eventsa

Neurologic (SyAE)
Guillain-Barré syndrome, new onset seizures, encephalitis, myelitis, altered mental status, focal cranial or peripheral neurologic deficits, paresthesias, vertigo, headaches (headaches alone are not sufficient for neurologic diagnosis)b
Onset <2 weeks after vaccination
Duration >72 hours
Multisystemic (SyAE)
Myalgias, arthralgias, rhabdomyolysis, elevated transaminases, respiratory distress, nausea, vomiting, diarrhea, nephropathy, disseminated intravascular coagulation, +/-feverb
Onset <2 weeks after vaccination
Duration >72 hours
Neurologic/systemic, uncomplicated (OAE)
Cases that met the neurologic or systemic criteria but had a full and rapid clinical recovery in <72 hours
Nonspecific events without other focal finding (OAE)
Dizziness, headache
Nausea, vomiting, or diarrhea alone
Hypersensitivity (OAE)
Rash, urticaria, +/- fever
Anaphylaxis, angioedema
Onset within 48 hours of vaccination
Local reaction (OAE)
Localized pain, swelling, erythema, or warmth (at injection site)
Onset within 1 week of vaccination
Unrelated to vaccine (excluded from AE analysis)
A clear, alternative diagnosis confirmed by laboratory criteria accounts for symptoms and signs; sometimes this is an underlying illness
Another cause implied or stated in the physician's report
For hepatitis A vaccine, onset of adverse event is >6 weeks

aListed in order from most to least severe.
bExamples, but not limited to these signs, symptoms and conditions.
SyAE = systemic adverse event; OAE = other adverse events; AE = adverse event(s).

Main Article

1Jeff Altman, University of Washington, Seattle, Washington; Vernon Ansdell, Kaiser Permanente, Honolulu, Hawaii; Elizabeth Barnett, Boston University, Boston, Massachusetts; Michele Barry Yale University, New Haven, Connecticut; Bradley Connor, Cornell University, New York, New York; David Freedman, University of Alabama at Birmingham, Birmingham, Alabama; Alejandra Gurtman, Mount Sinai Medical Center, New York, New York; Elaine Jong, University of Washington, Seattle, Washington; Phyllis Kozarsky, Emory University, Atlanta, Georgia; Russell McMullen, University of Washington, Seattle, Washington; Jan Patterson, University of Texas, San Antonio, Texas; Bradley Sack, Johns Hopkins University, Baltimore, Maryland; Mary E. Wilson, Harvard University, Cambridge, Massachusetts; Martin Wolfe, Traveler's Medical Service of Washington, Washington, D.C.

Page created: December 09, 2010
Page updated: December 09, 2010
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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