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Volume 7, Number 6—December 2001


Advanced Age a Risk Factor for Illness Temporally Associated with Yellow Fever Vaccination

Michael Martin*†, Leisa H. Weld*, Theodore F. Tsai*, Gina T. Mootrey*, Robert T. Chen*, Manette Niu‡, Martin S. Cetron*, and the GeoSentinel Yellow Fever Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;; †Emory School of Medicine, Atlanta, Georgia, USA;; ‡Center for Biologic Evaluation, U.S. Food and Drug Administration, Rockville, Maryland, USA

Main Article

Table 2

Reporting rates (RR) and reporting rate ratios (RRR) for yellow fever (YF) vaccine adverse events by age, 1990-1998

Age (years) No. doses No. OAEa OAE reports/100,000 doses RRR (95% CI) No. SyAEb SyAE reports/ 100,000 doses RRR (95% CI)
15-24 189,991 11 5.79 2.5 (1.2-5.5) 3 1.58 1.0 (0.3-3.6)
25-44 702,783 16 2.28 Ref. 11 1.57 Ref.
45-64 442,605 8 1.81 0.8 (0.3-1.9) 12 2.71 1.7 (0.8-3.9)
65-74 86,222 1 1.16 0.5 (0.1-3.8) 5 5.80 3.7 (1.3-10.7)
>75 22,085 0 0 undefined 4 18.11 11.6 (3.7-36)
Total 1,443,686 36 2.49 35 2.42

CI = confidence intervals; Ref = reference.
aOAE: other adverse event (uncomplicated neurologic/systemic, hypersensitivity, or local reaction).
bSyAE: systemic adverse event (multisystemic [excluding anaphylactic] or neurologic reaction).

Main Article

1Jeff Altman, University of Washington, Seattle, Washington; Vernon Ansdell, Kaiser Permanente, Honolulu, Hawaii; Elizabeth Barnett, Boston University, Boston, Massachusetts; Michele Barry Yale University, New Haven, Connecticut; Bradley Connor, Cornell University, New York, New York; David Freedman, University of Alabama at Birmingham, Birmingham, Alabama; Alejandra Gurtman, Mount Sinai Medical Center, New York, New York; Elaine Jong, University of Washington, Seattle, Washington; Phyllis Kozarsky, Emory University, Atlanta, Georgia; Russell McMullen, University of Washington, Seattle, Washington; Jan Patterson, University of Texas, San Antonio, Texas; Bradley Sack, Johns Hopkins University, Baltimore, Maryland; Mary E. Wilson, Harvard University, Cambridge, Massachusetts; Martin Wolfe, Traveler's Medical Service of Washington, Washington, D.C.