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Volume 7, Number 6—December 2001
Research

Advanced Age a Risk Factor for Illness Temporally Associated with Yellow Fever Vaccination

Michael Martin*†, Leisa H. Weld*, Theodore F. Tsai*, Gina T. Mootrey*, Robert T. Chen*, Manette Niu‡, Martin S. Cetron*, and the GeoSentinel Yellow Fever Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;; †Emory School of Medicine, Atlanta, Georgia, USA;; ‡Center for Biologic Evaluation, U.S. Food and Drug Administration, Rockville, Maryland, USA

Main Article

Table 3

Reporting rates (RR) and reporting rate ratios (RRR) for serious systemic yellow fever (YF) vaccine adverse events (SyAE*) by age, 1990-1998

Age Years No. vaccine doses No. of OAE*a OAE* reported/
100,000 doses RRR (95% CI) #SyAE*b SyAE* reported/
100,000 doses RRR (95% CI)
15-24 189,991 12 6.32 1.8 (0.9-3.5) 2 1.05 3.7 (0.5-26)
25-44 702,783 25 3.56 Reference 2 0.29 Reference
45-64 442,605 15 3.39 1.0 (0.5-1.8) 5 1.13 4.0 (0.8-20)
65-74 86,222 3 3.48 1.0 (0.3-3.2) 3 3.48 12.3 (2.0-73)
>75 22,085 2 9.06 2.5 (0.6-10.7) 2 9.06 32 (4.5-226)
Total 1,443,686 57 3.95 14 0.97

aOAE*= other adverse events (i.e., uncomplicated neurologic or systemic event; hypersensitivity; local reaction) OR systemic adverse events not requiring hospitalization or resulting in death.
bSyAE* = serious systemic adverse events, including only neurologic or multisystemic adverse events requiring hospitalization or resulting in death; this is distinguished from the term SyAE, which indicates all systemic adverse events (See Table 2).
CI = confidence intervals.

Main Article

1Jeff Altman, University of Washington, Seattle, Washington; Vernon Ansdell, Kaiser Permanente, Honolulu, Hawaii; Elizabeth Barnett, Boston University, Boston, Massachusetts; Michele Barry Yale University, New Haven, Connecticut; Bradley Connor, Cornell University, New York, New York; David Freedman, University of Alabama at Birmingham, Birmingham, Alabama; Alejandra Gurtman, Mount Sinai Medical Center, New York, New York; Elaine Jong, University of Washington, Seattle, Washington; Phyllis Kozarsky, Emory University, Atlanta, Georgia; Russell McMullen, University of Washington, Seattle, Washington; Jan Patterson, University of Texas, San Antonio, Texas; Bradley Sack, Johns Hopkins University, Baltimore, Maryland; Mary E. Wilson, Harvard University, Cambridge, Massachusetts; Martin Wolfe, Traveler's Medical Service of Washington, Washington, D.C.

Page created: December 09, 2010
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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