Volume 7, Number 7—June 2001
THEME ISSUE
International Conference on Emerging Infectious Diseases 2000
Conference Presentations
Epidemiology, Evolution, and Future of the HIV/AIDS Pandemic
Bruce R. Levin*
, J. J. Bull†, and Frank M. Stewart‡
, J. J. Bull†, and Frank M. Stewart‡
Table 2
Years before the frequency of a gene that confers a 10% advantagea to reach 0.50
| Mode of inheritance |
|||
|---|---|---|---|
| Initial frequency | No dominance | Dominant | Recessive |
| 0.01 | 1,838 | 1,054 | 41,038 |
| 0.001 | 2,763 | 1,964 | 401,963 |
| 0.0001 | 3,684 | 2,884 | 4,002,884 |
aWe are assuming that favored genotype has a 10% advantage over the other genotypes; in the no dominance case, the relative fitness of the heterozygote is intermediate between that of the two homozygotes. With a 1% selective advantage, it would take 10 times as long for the gene to reach a frequency of 50%.
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