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Volume 7, Number 7—June 2001
International Conference on Emerging Infectious Diseases 2000
Conference Presentations

Epidemiology, Evolution, and Future of the HIV/AIDS Pandemic

Bruce R. Levin*Comments to Author , J. J. Bull†, and Frank M. Stewart‡
Author affiliations: *Emory University, Atlanta, Georgia, USA; †University of Texas, Austin, Texas, USA; ‡Brown University, Providence, Rhode Island, USA

Main Article

Table 2

Years before the frequency of a gene that confers a 10% advantagea to reach 0.50

Mode of inheritance
Initial frequency No dominance Dominant Recessive
0.01 1,838 1,054 41,038
0.001 2,763 1,964 401,963
0.0001 3,684 2,884 4,002,884

aWe are assuming that favored genotype has a 10% advantage over the other genotypes; in the no dominance case, the relative fitness of the heterozygote is intermediate between that of the two homozygotes. With a 1% selective advantage, it would take 10 times as long for the gene to reach a frequency of 50%.

Main Article

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