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Volume 10, Number 11—November 2004
Research

Topographic Changes in SARS Coronavirus–infected Cells during Late Stages of Infection

Mah-Lee Ng*Comments to Author , J.W.M. Lee*, M.L.N. Leong*, A.-E. Ling†, H.-C. Tan‡, and E.E. Ooi‡
Author affiliations: *National University of Singapore, Singapore; †Singapore General Hospital, Singapore; ‡National Environment Agency, Singapore

Main Article

Figure 2

Scanning electron microscopy of Vero E6 cells infected with severe acute respiratory syndrome–associated coronavirus at 15 h after infection. A) One pronounced surface morphologic change is the proliferation of psuedopodia at the cell periphery (arrows). Some pseudopodia are also developing on the cell surface. Some cells appear to have large amount of extracellular virus on the cell surface (arrowhead), whereas neighboring cells seem deprived of any extracelluar virus particles. B) Virus partic

Figure 2. Scanning electron microscopy of Vero E6 cells infected with severe acute respiratory syndrome–associated coronavirus at 15 h after infection. A) One pronounced surface morphologic change is the proliferation of psuedopodia at the cell periphery (arrows). Some pseudopodia are also developing on the cell surface. Some cells appear to have large amount of extracellular virus on the cell surface (arrowhead), whereas neighboring cells seem deprived of any extracelluar virus particles. B) Virus particles are protruding from the edge of cells (arrows). Inset shows the boxed area at higher magnification. Virus particles appear knobby and rosettelike.

Main Article

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Page updated: April 21, 2011
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