Volume 10, Number 8—August 2004
Research
Predicting Antigenic Variants of Influenza A/H3N2 Viruses
Min-Shi Lee*
and Jack Si-En Chen*
and Jack Si-En Chen*
Table 3
Some unique pairwise comparisons showing antigenic distance and amino acid changes
| Viruses compared | Antigenic distance (ferret HAI titers)a | Amino acid changes (antigenic sites) |
|---|---|---|
| A/Shanghai/11/87 vs. A/Victoria/7/87 |
5.7 ([320 x 320]/[40 x 80])½ |
R247S(D) |
| A/Shanghai/11/87 vs. A/Sichuan/2/87 |
2.8 ([320 x 640]/[160 x 160])½ |
E156K(B), S186V(B), R247S(D) |
| A/Shanghai/11/87 vs. A/Sydney/1/87 |
2.0 ([320 x 320]/[160x 160])½ |
A138S(A), N193K(B), R247S(D) |
| A/Sichuan/2/87 vs. A/Victoria/7/87 |
5.7 ([320 x 640]/[40 x 160])½ |
K156E(B),V186S(B) |
| A/Sydney/1/87 vs. A/Victoria/7/87 |
4.0 ([320 x 320]/[80 x 80])½ |
S138A(A), K193N(B) |
| A/Victoria/3/75 vs. A/Victoria/112/76 |
5.7 ([640 x 2,560]/[640 x 80]) ½ |
L3F, R229G(D) |
| A/Sydney/5/97 vs. A/Panama/2007/99 |
1.4([5,120x 2,560]/[2,560 x 2,560])½ |
I3L, P21S, R57Q(E), Y137S(A), S142R(A), I144N(A), D172E(D), H183L, T192I(B), I194L(B), I226V(D), H233Y |
| A/Fujian/140/2000 vs. A/HK/1550/2002 |
2.0 ([640 x 640]/[320 x 320])½ |
G14C, A43V, R50G(C), E83K(E), N96S(D), S186V(B), V194I(B), P199S, V202I, W222R, G225D, I226V(D), C247S(D), S273P(C) |
| A/Chile/6416/01 vs. A/HK/1550/02 | 2.0 ([320 x 640]/[80 x 640])½ | R50G(C), E83K(E), N96S(D), V106A, D144N(A), G186V(B), L194I(B), V202I, H221P, W222R, G225D, K246N(D) |
aHemagglutinin-inhibition (HAI) titers were shown as two homologous titers divided by two heterologous titers.
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