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Volume 15, Number 1—January 2009
Dispatch

Microsporidiosis and Malnutrition in Children with Persistent Diarrhea, Uganda

Siobhan M. MorComments to Author , James K. Tumwine, Elena N. Naumova, Grace Ndeezi, and Saul Tzipori
Author affiliations: Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA (S.M. Mor, S. Tzipori); Tufts University School of Medicine, Boston, Massachusetts, USA (S.M. Mor, E.N. Naumova); Makerere University Medical School, Kampala, Uganda (J.K. Tumwine, G. Ndeezi)

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Figure 2

Weight-for-age growth curves of study children (as modeled by multiple linear regression) and reference populations in Uganda (11). Curves represent the median weight-for-age, averaged between boys and girls and controlling for concurrent Cryptosporidium spp. infection. The difference, 95% confidence interval, and significance of the interaction term between Enterocytozoon bieneusi and age reflect the difference in growth rates of children with and without microsporidiosis in ln(kg)/ln(age). R2

Figure 2. Weight-for-age growth curves of study children (as modeled by multiple linear regression) and reference populations in Uganda (11). Curves represent the median weight-for-age, averaged between boys and girls and controlling for concurrent Cryptosporidium spp. infection. The difference, 95% confidence interval, and significance of the interaction term between Enterocytozoon bieneusi and age reflect the difference in growth rates of children with and without microsporidiosis in ln(kg)/ln(age). R2 = 0.42, difference = –0.133, 95% confidence interval –0.23 to –0.03, p = 0.009.

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References
  1. Schmidt  W, Schneider  T, Heise  W, Schulzke  JD, Weinke  T, Ignatius  R, Mucosal abnormalities in microsporidiosis. AIDS. 1997;11:1589–94. DOIPubMedGoogle Scholar
  2. Kotler  DP, Francisco  A, Clayton  F, Scholes  JV, Orenstein  JM. Small intestinal injury and parasitic diseases in AIDS. Ann Intern Med. 1990;113:444–9.PubMedGoogle Scholar
  3. Molina  JM, Sarfati  C, Beauvais  B, Lemann  M, Lesourd  A, Ferchal  F, Intestinal microsporidiosis in human immunodeficiency virus-infected patients with chronic unexplained diarrhea: prevalence and clinical and biologic features. J Infect Dis. 1993;167:217–21.PubMedGoogle Scholar
  4. Lambl  BB, Federman  M, Pleskow  D, Wanke  CA. Malabsorption and wasting in AIDS patients with microsporidia and pathogen-negative diarrhea. AIDS. 1996;10:739–44. DOIPubMedGoogle Scholar
  5. Asmuth  DM, DeGirolami  PC, Federman  M, Ezratty  CR, Pleskow  DK, Desai  G, Clinical features of microsporidiosis in patients with AIDS. Clin Infect Dis. 1994;18:819–25.PubMedGoogle Scholar
  6. Tumwine  JK, Kekitiinwa  A, Bakeera-Kitaka  S, Ndeezi  G, Downing  R, Feng  X, Cryptosporidiosis and microsporidiosis in Ugandan children with persistent diarrhea with and without concurrent infection with the human immunodeficiency virus. Am J Trop Med Hyg. 2005;73:921–5.PubMedGoogle Scholar
  7. Tumwine  JK, Kekitiinwa  A, Nabukeera  N, Akiyoshi  DE, Buckholt  MA, Tzipori  S. Enterocytozoon bieneusi among children with diarrhea attending Mulago Hospital in Uganda. Am J Trop Med Hyg. 2002;67:299–303.PubMedGoogle Scholar
  8. Leelayoova  S, Vithayasai  N, Watanaveeradej  V, Chotpitayasunondh  T, Therapong  V, Naaglor  T, Intestinal microsporidiosis in HIV-infected children with acute and chronic diarrhea. Southeast Asian J Trop Med Public Health. 2001;32:33–7.PubMedGoogle Scholar
  9. Wanachiwanawin  D, Chokephaibulkit  K, Lertlaituan  P, Ongrotchanakun  J, Chinabut  P, Thakerngpol  K. Intestinal microsporidiosis in HIV-infected children with diarrhea. Southeast Asian J Trop Med Public Health. 2002;33:241–5.PubMedGoogle Scholar
  10. Tumwine  JK, Kekitiinwa  A, Nabukeera  N, Akiyoshi  DE, Rich  SM, Widmer  G, Cryptosporidium parvum in children with diarrhea in Mulago Hospital, Kampala, Uganda. Am J Trop Med Hyg. 2003;68:710–5.PubMedGoogle Scholar
  11. Cortinovis  I, Vella  V, Ndiku  N, Milani  S. Weight, height and arm circumference of children under 5 in the district of Mbarara, south-west Uganda. Ann Hum Biol. 1997;24:557–68. DOIPubMedGoogle Scholar
  12. Leelayoova  S, Subrungruang  I, Rangsin  R, Chavalitshewinkoon-Petmitr  P, Worapong  J, Naaglor  T, Transmission of Enterocytozoon bieneusi genotype a in a Thai orphanage. Am J Trop Med Hyg. 2005;73:104–7.PubMedGoogle Scholar
  13. Samie  A, Obi  CL, Tzipori  S, Weiss  LM, Guerrant  RL. Microsporidiosis in South Africa: PCR detection in stool samples of HIV-positive and HIV-negative individuals and school children in Vhembe district, Limpopo Province. Trans R Soc Trop Med Hyg. 2007;101:547–54. DOIPubMedGoogle Scholar
  14. Espern  A, Morio  F, Miegeville  M, Illa  H, Abdoulaye  M, Meyssonnier  V, Molecular study of microsporidiosis due to Enterocytozoon bieneusi and Encephalitozoon intestinalis among human immunodeficiency virus–infected patients from two geographical areas: Niamey, Niger, and Hanoi, Vietnam. J Clin Microbiol. 2007;45:2999–3002. DOIPubMedGoogle Scholar
  15. McMurray  C. Cross-sectional anthropometry: what can it tell us about the health of young children? Health Transit Rev. 1996;6:147–68.PubMedGoogle Scholar

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