Volume 15, Number 7—July 2009
Research
Clusters of Multidrug-Resistant Mycobacterium tuberculosis Cases, Europe
Isabelle Devaux
, Kristin Kremer, Herre Heersma, and Dick van Soolingen
, Kristin Kremer, Herre Heersma, and Dick van Soolingen
Table 5
Predictors for TB caused by Beijing strains among 506 cases reported in 16 European countries, January 2003 through June 2007*
| Variable | MDR TB strains |
Unadjusted OR (95% CI) | Adjusted† OR (95% CI) | |
|---|---|---|---|---|
| No. patients | % Beïjing strains | |||
| Sex | ||||
| Male | 333 | 58 | 1 | 1 |
| Female |
164 |
55 |
0.9 (0.6–1.3) |
1.1 (0.5–2.4) |
| Age | ||||
| 15–44 | 313 | 53 | 1 | 1 |
| 45–64 | 142 | 67 | 1.7 (1.1–2.6) | 1.0 (0.5–2.1) |
| >65 |
30 |
70 |
2.5 (1.1–5.5) |
2.3 (0.5–10.4) |
| Origin | ||||
| Baltic states | 188 | 92 | 154.5 (54.0–442.0) | 173.8 (45.5–663.6) |
| Other FSU countries‡ | 99 | 75 | 39.7 (14.4–109.5) | 32.2 (8.6–120.8) |
| Other European countries | 71 | 6 | 1 | 1 |
| Africa |
71 |
10 |
1.5 (0.4–4.9) |
1.1 (0.2–5.5) |
| Site of disease | ||||
| Pulmonary | 455 | 59 | 3.4 (1.7–6.6) | 0.7 (0.1–3.3) |
| Extrapulmonary |
40 |
30 |
1 |
1 |
| Previous TB | ||||
| Yes | 156 | 64 | 1.1 (0.8–1.7) | 1.0 (0.5–2.0) |
| No |
245 |
62 |
1 |
1 |
| Clustering | ||||
| Yes | 250 | 87% | 19.0 (12.0–30.3) | – |
| No |
250 |
26% |
1 |
|
| XDR TB | ||||
| Yes | 51 | 90 | 5.5 (2.1–14.3) | – |
| No | 341 | 62 | 1 | |
*TB, tuberculosis; MDR, multidrug-resistant; OR, odds ratio; CI, confidence interval; FSU, former Soviet Union; XDR, extensively drug-resistant. Boldface indicates significance.
†For all other factors in the model except XDR TB.
‡Former Soviet Union countries: Azerbaijan, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Ukraine, and Uzbekistan.
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