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Volume 2, Number 4—October 1996
Synopsis

A Mathematical Model and CD4+ Lymphocyte Dynamics in HIV Infection

Tomáš Hraba* and Jaroslav Dolezal†
Author affiliations: *Institute of Molecular Genetics, Prague, Czech Republic; †Honeywell Technology Center, Prague, and Institute of Information Theory and Automation, Prague, Czech Republic

Main Article

Figure 6

Simulated CD4+ and CD8+ lymphocyte dynamics after permanent treatment with anti-CD8 antibodies started 2 years after the acquisition of the HIV infection. Cells mediating the protective anti-HIV immune reaction are also affected by this treatment (R = 0.007, C = 0.007). *CD4+ cell observed values are depicted as circles and those of CD8+ lymphocytes as squares. Both simulated and observed values are depicted as a percentage of normal CD4+ lymphocyte numbers (the normal value of CD8+ lymphocytes

Figure 6. Simulated CD4+ and CD8+ lymphocyte dynamics after permanent treatment with anti-CD8 antibodies started 2 years after the acquisition of the HIV infection. Cells mediating the protective anti-HIV immune reaction are also affected by this treatment (R = 0.007, C = 0.007). *CD4+ cell observed values are depicted as circles and those of CD8+ lymphocytes as squares. Both simulated and observed values are depicted as a percentage of normal CD4+ lymphocyte numbers (the normal value of CD8+ lymphocytes is thus 66.7%).

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