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Volume 10, Number 7—July 2004
Research

Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001

Pak-Leung Ho*Comments to Author , Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*
Author affiliations: *Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), China; †Tuen Mun Hospital, Hong Kong SAR, China; ‡Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China; §Princess Margaret Hospital, Hong Kong, SAR, China; ¶Queen Elizabeth Hospital, Hong Kong SAR, China

Main Article

Table 1

MICs of 11 antimicrobial agents for Streptococcus pneumoniae isolates based on susceptibility to penicillina,b

Antimicrobial agent and penicillin susceptibility status
 MIC (μg/mL)
 % of Isolates
Range
 50%
 90%
 Mode
 S
 I
 R
Penicillin
  All
 0.008−4
 0.032
 2
 0.016
 62.6
 20.0
 17.4
  Pen-S
 0.008−0.064
 0.016
 0.032
 0.016
 100
 0.0
 0.0
  Pen-I
 0.125−1
 1
 1
 1
 0.0
 100
 0.0
  Pen-R
 2−4
 2
 2.0
 2
 0.0
 0.0
 100
Amoxicillin
  All
 0.016−4
 0.032
 2
 0.016
 99.6
 0.4
 0.0
  Pen-S
 0.016−0.125
 0.016
 0.032
 0.016
 100.0
 0.0
 0.0
  Pen-I
 0.032−2
 1
 2
 1
 100.0
 0.0
 0.0
  Pen-R
 0.5−4
 2
 2
 2
 97.8
 2.2
 0.0
Cefotaxime
  All
 0.016−4
 0.032
 1
 0.016
 97.0
 2.6
 0.4
  Pen-S
 0.016−0.125
 0.016
 0.032
 0.016
 100.0
 0.0
 0.0
  Pen-I
 0.032−2
 1
 1
 1
 100.0
 0.0
 0.0
  Pen-R
 0.5−4
 1
 2
 1
 82.6
 15.2
 2.2
Cefepime
  All
 0.016−4
 0.064
 2
 0.064
 76.2
 21.9
 1.9
  Pen-S
 0.016−0.25
 0.064
 0.125
 0.064
 100.0
 0.0
 0.0
  Pen-I
 0.032−1
 1
 2
 2
 66.0
 34.0
 0.0
  Pen-R
 1−4
 2
 2
 2
 2.2
 87
 10.9
Clarithromycin
  All
 0.032−256
 4
 256
 256
 36.6
 0.4
 63.0
  Pen-S
 0.032−256
 0.125
 256
 0.125
 56.0
 0.0
 44.0
  Pen-I
 0.064−256
 256
 256
 256
 7.5
 1.9
 90.6
  Pen-R
 2−256
 4
 256
 2
 0.0
 0.0
 100.0
Vancomycin
  All
 0.25−1
 0.5
 0.5
 0.5
 100.0
 0.0
 0.0
  Pen-S
 0.25−1
 0.5
 0.5
 0.5
 100.0
 0.0
 0.0
  Pen-I
 0.25−1
 0.5
 0.5
 0.5
 100.0
 0.0
 0.0
  Pen-R
 0.25−1
 0.5
 1
 0.5
 100.0
 0.0
 0.0
Ciprofloxacin
  All
 0.25−32
 1
 1
 1
 95.8
 −
 4.2
  Pen-S
 0.25−4
 1
 1
 1
 99.4
 −
 0.6
  Pen-I
 0.25−32
 1
 1
 1
 94.3
 −
 5.7
  Pen-R
 0.5−32
 1
 32
 1
 84.8
 −
 15.2
Levofloxacin
  All
 0.125−32
 1
 1
 1
 96.2
 0.0
 3.8
  Pen-S
 0.125−2
 1
 1
 1
 100.0
 0.0
 0.0
  Pen-I
 0.125−32
 1
 1
 1
 94.3
 0.0
 5.7
  Pen-R
 0.5−32
 1
 32
 1
 84.8
 0.0
 15.2
Sparfloxacin
  All
 0.125−32
 0.25
 0.5
 0.5
 95.8
 0.8
 3.2
  Pen-S
 0.125−1
 0.25
 0.5
 0.5
 99.4
 0.6
 0.0
  Pen-I
 0.125−32
 0.25
 0.5
 0.5
 94.3
 0.0
 5.7
  Pen-R
 0.25−32
 0.5
 32
 0.5
 84.8
 2.2
 13.0
Gatifloxacin
  All
 0.064−16
 0.25
 0.25
 0.25
 96.2
 0.8
 3.0
  Pen-S
 0.064−1
 0.25
 0.25
 0.25
 100.0
 0.0
 0.0
  Pen-I
 0.125−8
 0.25
 0.25
 0.25
 94.3
 1.9
 3.8
  Pen-R
 0.125−16
 0.25
 8
 0.25
 84.8
 2.2
 13.0
Moxifloxacin
  All
 0.064−8
 0.125
 0.25
 0.125
 97.0
 0.8
 2.3
  Pen-S
 0.064−1
 0.125
 0.25
 0.125
 100.0
 0.0
 0.0
  Pen-I
 0.064−4
 0.125
 0.25
 0.125
 96.2
 1.9
 1.9
  Pen-R 0.125−8 0.125 4 0.125 87.0 2.2 10.9

aN = 265; a total of 166 isolates were penicillin-susceptible (Pen-S), 53 were penicillin-intermediate (Pen-I), and 46 were penicillin-resistant (Pen-R).

b50% and 90%, MIC50 and MIC90, respectively.

Main Article

Page created: January 27, 2011
Page updated: January 27, 2011
Page reviewed: January 27, 2011
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