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Volume 10, Number 7—July 2004
Research

Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001

Pak-Leung Ho*Comments to Author , Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*
Author affiliations: *Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), China; †Tuen Mun Hospital, Hong Kong SAR, China; ‡Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China; §Princess Margaret Hospital, Hong Kong, SAR, China; ¶Queen Elizabeth Hospital, Hong Kong SAR, China

Main Article

Table 3

Characteristics of 11 strains of Streptococcus pneumoniae with reduced susceptibility to ciprofloxacin

Strain
 Y
 Source
 Serotypea
 MLST profile
 MIC (μg/mL)
 Mutation in QRDR ofcd
CIP
 LVX
 GAT
 MO
 GyrA
 ParC
 ParE
S3F7
 1996
 A
 23F
 4-4-2-4-4-1-1
 32
 32
 2
 1
 S81F
 K137N
 E474K, I460V
S2H9
 1997
 A
 23F
 4-4-2-4-4-1-1
 32
 32
 4
 2
 S81Y
 K137N
 D435N, I460V
S1B7
 1999
 B
 23F
 4-4-2-4-4-1-1
 32
 32
 8
 4
 S81F
 S79F, K137N
 I460V
S1B9
 1999
 B
 23F
 4-4-2-4-4-1-1
 32
 32
 16
 4
 S81F
 S79F, K137N
 I460V
S1D5
 1999
 C
 19F
 4-4-2-4-4-1-1
 32
 32
 8
 4
 S81F
 S79F, K137N
 I460V
S2D6
 1999
 A
 14
 4-4-2-4-4-1-1
 32
 32
 8
 4
 S81F
 S79F, K137N
 I460V
S1D2
 2000
 C
 19F
 4-4-2-4-4-1-1
 32
 32
 8
 8
 S81F
 S79F, K137N
 -
S1D3 2000 C 4 8-8-8-1-17-1-18 4 2 0.5 0.25 - K137N I460V

aMLST, multilocus sequence typing. Number refers to allelle of aroE, gdh, gki, recP, spi, xpt, and ddiA genes, respectively.

bCIP, ciprofloxacin; LVX, levofloxacin; GAT, gatifloxacin; MO, moxifloxacin.

cNo strains had mutations in GyrB sequence.

dS. pneumoniae numbering.

Main Article

Page created: January 27, 2011
Page updated: January 27, 2011
Page reviewed: January 27, 2011
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