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Volume 14, Number 6—June 2008


Validation of Syndromic Surveillance for Respiratory Pathogen Activity

Cees van den Wijngaard*Comments to Author , Liselotte van Asten*, Wilfrid van Pelt*, Nico J.D. Nagelkerke†, Robert Verheij‡, Albert J. de Neeling*, Arnold Dekkers*, Marianne A.B. van der Sande*, Hans van Vliet*, and Marion P.G. Koopmans*
Author affiliations: *National Institute for Public Health and the Environment, Bilthoven, the Netherlands; †United Arab Emirates University, Al-Ain, United Arab Emirates; ‡Netherlands Institute of Health Services Research, Utrecht, the Netherlands;

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Table 5

Syndrome variation that can be explained by either the pathogen counts, 
seasonal terms, or pathogen counts and seasonal terms together*

Syndrome data Pathogens, % Pathogens and seasonal terms, % Seasonal terms, %
Absenteeism 68 80 79
GP 86 89 75
Pharmacy 80 87 77
Hospitalization 84 88 75
Laboratory submissions 61 63 53
Mortality 78 78 52

*Estimated by 3 different R2 values for each registry: 1) for the syndromes explained by pathogen counts alone; 2) after adding seasonal terms to the pathogen model; and 3) for the syndromes explained by seasonal terms alone (sine and cosine parameters). GP, general practice.

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