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Volume 15, Number 12—December 2009
Research

Landscape Epidemiology of Tularemia Outbreaks in Sweden

Kerstin Svensson, Erik Bäck, Henrik Eliasson, Lennart Berglund, Malin Granberg, Linda Karlsson, Pär Larsson, Mats Forsman, and Anders JohanssonComments to Author 
Author affiliations: Swedish Defense Research Agency, Umeå, Sweden (K. Svensson, M. Granberg, L. Karlsson, P. Larsson, M. Forsman, A. Johansson); Umeå University, Umeå (K. Svensson, A. Johansson); Örebro University Hospital, Örebro, Sweden (E. Bäck, H. Eliasson); Ljusdal Healthcare Centre, Ljusdal, Sweden (L. Berglund); Umeå University Hospital, Umeå (A. Johansson)

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Figure 5

Attributes of 19 genotypes of Francisella tularensis subsp. holarctica identified in this study, and their genetic associations as assessed by a phylogenetic method (the clustering tree) or by an allele-based method (the genetic group designations). The letter and number designations in the clustering tree refer to nomenclatures of F. tularensis genetic clades as described by Johansson et al. (9). Gray shading indicates the derived genetic marker states. INDEL, insertion/deletion; SNP, single nu

Figure 5. Attributes of 19 genotypes of Francisella tularensis subsp. holarctica identified in this study, and their genetic associations as assessed by a phylogenetic method (the clustering tree) or by an allele-based method (the genetic group designations). The letter and number designations in the clustering tree refer to nomenclatures of F. tularensis genetic clades as described by Johansson et al. (9). Gray shading indicates the derived genetic marker states. INDEL, insertion/deletion; SNP, single nucleotide polymorphism; VNTR, variable number of tandem repeats; ID, identification.

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References
  1. Centers for Disease Control and Prevention. Emergency preparedness and response. Bioterrorism [cited 2009 Mar 31]. Available from http://www.bt.cdc.gov/agent/agentlist-category.asp
  2. Keim  P, Johansson  A, Wagner  DM. Molecular epidemiology, evolution, and ecology of Francisella. Ann N Y Acad Sci. 2007;1105:3066. DOIPubMedGoogle Scholar
  3. Penn  RL. Francisella tularensis (tularemia). In: Mandell GL, Bennet JE, Dolin R, editors. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 6th ed. Edinburgh (Scotland): Churchill Livingstone Ltd; 2005. p. 2674–85.
  4. Dennis  DT, Inglesby  TV, Henderson  DA, Bartlett  JG, Ascher  MS, Eitzen  E, Tularemia as a biological weapon: medical and public health management. JAMA. 2001;285:276373. DOIPubMedGoogle Scholar
  5. Eliasson  H, Bäck  E. Tularaemia in an emergent area in Sweden: an analysis of 234 cases in five years. Scand J Infect Dis. 2007;39:8809. DOIPubMedGoogle Scholar
  6. Johansson  A, Berglund  L, Eriksson  U, Göransson  I, Wollin  R, Forsman  M, Comparative analysis of PCR versus culture for diagnosis of ulceroglandular tularemia. J Clin Microbiol. 2000;38:226.PubMedGoogle Scholar
  7. Swedish Institute for Infectious Disease Control. Data and statistics. Tularaemia [cited 2009 Mar 31]. Available from http://www.smittskyddsinstitutet.se/in-english/statistics/tularaemia
  8. Centers for Disease Control and Prevention. Summary of notifiable diseases—United States, 2000–2006. MMWR Morb Mortal Wkly Rep [cited 2009 Mar 10]. Available from http://www.cdc.gov/mmwr/summary.html
  9. Johansson  A, Farlow  J, Larsson  P, Dukerich  M, Chambers  E, Byström  M, Worldwide genetic relationships among Francisella tularensis isolates determined by multiple-locus variable-number tandem repeat analysis. J Bacteriol. 2004;186:580818. DOIPubMedGoogle Scholar
  10. Achtman  M. Evolution, population structure, and phylogeography of genetically monomorphic bacterial pathogens. Annu Rev Microbiol. 2008;62:5370. DOIPubMedGoogle Scholar
  11. Statistics Sweden. Population statistics database [cited 2009 Mar 31]. Available from http://www.ssd.scb.se
  12. Olin  G. The occurrence and mode of transmission of tularemia in Sweden. Acta Pathol Microbiol Scand. 1942;19:22047.
  13. Eliasson  H, Sjöstedt  A, Bäck  E. Clinical use of a diagnostic PCR for Francisella tularensis in patients with suspected ulceroglandular tularaemia. Scand J Infect Dis. 2005;37:8337. DOIPubMedGoogle Scholar
  14. World Health Organization. WHO guidelines on tularemia. Geneva: The Organization; 2007 [cited 2009 Mar 31]. Available from http://www.who.int/csr/resources/publications/WHO_CDS_EPR_2007_7.pdf
  15. Larsson  P, Svensson  K, Karlsson  L, Guala  D, Granberg  M, Forsman  M, Canonical insertion-deletion markers for rapid DNA typing of Francisella tularensis. Emerg Infect Dis. 2007;13:172532.PubMedGoogle Scholar
  16. Germer  S, Higuchi  R. Homogeneous allele-specific PCR in SNP genotyping. Methods Mol Biol. 2003;212:197214.PubMedGoogle Scholar
  17. Feil  EJ, Enright  MC. Analyses of clonality and the evolution of bacterial pathogens. Curr Opin Microbiol. 2004;7:30813. DOIPubMedGoogle Scholar
  18. Sneath  PH, Sokal  RR, eds. Numerical taxonomy: the principles and practice of numerical classification. San Francisco: W.H. Freeman and Company; 1973.
  19. Lantmäteriet—the Swedish mapping, cadastral and land registration authority. RT 90 Coordinate system [cited 2009 Mar 31]. Available from http://www.lantmateriet.se
  20. Vogler  AJ, Birdsell  D, Price  LB, Bowers  JR, Beckstrom-Sternberg  SM, Auerbach  RK, Phylogeography of Francisella tularensis: global expansion of a highly fit clone. J Bacteriol. 2009;191:247484. DOIPubMedGoogle Scholar
  21. Petersen  JM, Carlson  JK, Dietrich  G, Eisen  RJ, Coombs  J, Janusz  AM, Multiple Francisella tularensis subspecies and clades, tularemia outbreak, Utah. Emerg Infect Dis. 2008;14:192830. DOIPubMedGoogle Scholar
  22. Farlow  J, Wagner  DM, Dukerich  M, Stanley  M, Chu  M, Kubota  K, Francisella tularensis in the United States. Emerg Infect Dis. 2005;11:183541.PubMedGoogle Scholar
  23. Staples  JE, Kubota  KA, Chalcraft  LG, Mead  PS, Petersen  JM. Epidemiologic and molecular analysis of human tularemia, United States, 1964–2004. Emerg Infect Dis. 2006;12:11138.PubMedGoogle Scholar
  24. Kugeler  KJ, Mead  PS, Janusz  AM, Staples  JE, Kubota  KA, Chalcraft  LG, Molecular epidemiology of Francisella tularensis in the United States. Clin Infect Dis. 2009;48:86370. DOIPubMedGoogle Scholar
  25. Larsson  P, Elfsmark  D, Svensson  K, Wikström  P, Forsman  M, Brettin  T, Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen. PLoS Pathog. 2009;5:e1000472. DOIPubMedGoogle Scholar
  26. Alland  D, Whittam  TS, Murray  MB, Cave  MD, Hazbon  MH, Dix  K, Modeling bacterial evolution with comparative-genome-based marker systems: application to Mycobacterium tuberculosis evolution and pathogenesis. J Bacteriol. 2003;185:33929. DOIPubMedGoogle Scholar
  27. Pearson  T, Busch  JD, Ravel  J, Read  TD, Rhoton  SD, U'Ren JM, et al. Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing. Proc Natl Acad Sci U S A. 2004;101:1353641. DOIPubMedGoogle Scholar
  28. Becker  N, Petric´  D, Zgomba  M, Boase  C, Dahl  C, Lane  J, Mosquitoes and their control. London: Kluwer Academic/Plenum Publishers; 2003.
  29. Schäfer  ML, Lundström  JO, Petersson  E. Comparison of mosquito (Diptera: Culicidae) populations by wetland type and year in the lower river Dalälven region, Central Sweden. J Vector Ecol. 2008;33:1507. DOIPubMedGoogle Scholar
  30. Pavlovsky  E. Natural nidality of transmissible diseases. Urbana (IL): University of Illinois Press; 1966.
  31. Goethert  HK, Telford  SR III. Nonrandom distribution of vector ticks (Dermacentor variabilis) infected by Francisella tularensis. PLoS Pathog. 2009;5:e1000319. DOIPubMedGoogle Scholar

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Page created: December 09, 2010
Page updated: December 09, 2010
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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