Volume 15, Number 6—June 2009
Lineage 2 West Nile Virus as Cause of Fatal Neurologic Disease in Horses, South Africa
|Case no.||Date sample received||Location||Specimen||Final diagnosis||Results of tests for other viruses|
|SAE12/07||2007 Apr 23||Johannesburg, Sandton, Gauteng||Plasma||WNV IgM+||AHSV–, EEV–|
|SAE89/08||2008 Mar 3||Colesburg North Cape||Plasma||WNV IgM+||AHSV–, EEV–|
|HS101/08||2008 Apr 15||Tiegerpoort Pretoria, Gauteng||Brain||WNV PCR+, DNA sequencing L2, virus isolae WNV PCR+||Rabies–, AHSV–, EEV–, EHV–, flavivirus antigen in lumbar spinal cord section and in some gray matter axons (Figure 1)|
|M123/08||2008 May 8||Midrand, Gauteng||Brain||WNV PCR+, DNA sequencing L2||AHSV–, EEV–, EHV–|
|HS125/08||2008 May 26||Pretoria, Hammans-kraal, Gauteng||Brain||WNV PCR+, DNA sequencing L2||AHSV from spleen PCR+; AHSV from lung IHC+, lymph node IHC–, liver IHC–|
|SAE126/08||2008 Mar 7||Midrand, Gauteng||Brain||WNV PCR+, DNA sequencing L2||AHSV RT-PCR+, AHSV type 7; IHC EEV–, AHSV+, AHSV IHC+ (lung liver, heart)|
|SAE134/09||2008 Jul 18||Potchef-stroom, North-Western Province||Serum||WNV PCR+, DNA sequencing L2||AHSV–, EEV–, EHV-1 weak sero+|
*WNV, West Nile virus, Ig, immunoglobuliln; AHSV, African horse sickness virus; EEV, equine encephalosis virus; EHV, equine herpesvirus; L2, lineage 2; –, negative; +, positive; RT-PCR, reverse transcription–PCR; IHC, immunohistochemistry.
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