Volume 17, Number 10—October 2011
Dispatch
Novel Arenavirus, Zambia
Akihiro Ishii
, Yuka Thomas, Ladslav Moonga, Ichiro Nakamura, Aiko Ohnuma, Bernard M. Hang’ombe, Ayato Takada, Aaron S. Mweene, and Hirofumi Sawa
, Yuka Thomas, Ladslav Moonga, Ichiro Nakamura, Aiko Ohnuma, Bernard M. Hang’ombe, Ayato Takada, Aaron S. Mweene, and Hirofumi Sawa
Table 2
Functional motifs in the Z and glycoprotein precursor proteins of Old World arenaviruses*
| Strain | Late domains† | Strain | S1P cleavage site‡ |
|---|---|---|---|
| LUNV (Lusaka) | PTAPKESASNPPPYSP | LUNV (Lusaka) | RRLM-GTFTW |
| LUNV (Namwala) | PTAPKEPARNPPPYSP | LUNV (Namwala) | RRLM-GTFTW |
| MOBV | PTAPPPEATNPPPYSP | MOBV | RRLM-GTFTW |
| MOPV | PTAPPEIPPSQNPPPYSP | IPPYV | RRLM-STFTW |
| MORV | PTAPPEAMPSQQPPPYQP | LUJV | RKLM-KLFQW |
| LASV | PTAPPTGAADSIRPPPYSP | MOPV | RRLL-GLFTW |
| IPPYV | PSAPPSPSPPPYSP | MORV | RRLL-GLFTW |
| LCMV | STAPSSPPPYEE§ | LASV | RRLL-GTFTW |
| DANV | STAPSSPPPYEE | LCMV | RRLA-GTFTW |
| LUJV | PSAPPL | DANV | RRLA-GTFTW |
*S1P, cellular proprotein convertase site 1 protease; LUNV, Luna virus; -, S1P cleavage site; MOBV, Mobala virus; MOPV, Mopeia virus; MORV, Morogoro virus; LASV, Lassa virus; IPPYV, Ippy virus; LCMV, lymphocytic choriomeningitis virus; DANV, Dandenong virus; LUJV, Lujo virus.
†Conserved P(T/S)AP and PPPY motifs in the Z protein are in boldface.
‡R(R/K)LM is considered a putative, although unconfirmed, S1P cleavage site.
§STAP is considered a putative, although unconfirmed, PTAP motif.
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Page updated: September 23, 2011
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