Volume 18, Number 1—January 2012
Research
Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
, Jay Lucidarme, Lynne S. Newbold, Stephen J. Gray, Anthony D. Carr, Jamie Findlow, Mary E. Ramsay, Edward B. Kaczmarski, and Raymond Borrow
Table 2
Clinical presentation of, risk factors for, and outcome of patients with invasive meningococcal capsular group Y disease, England and Wales, 2007–2009
| Variable | Age group, y, no. (%) patients |
Total, n = 65 | |||
|---|---|---|---|---|---|
| <25, n = 20 | 25–64, n = 19 | 65–84, n = 13 | >85, n = 13 | ||
| Female sex | 11 (55) | 14 (74) | 10 (77) | 12 (92) | 47 (72) |
| Travel* | 2 (10) | 2 (11) | 1 (8) | 0 | 5 (8) |
| Clinical feature | |||||
| Meningitis | 8 (40) | 11 (58) | 2 (15) | 1 (8) | 23 (35) |
| Pneumonia | 1 (5) | 3 (16) | 5 (39) | 10 (77) | 19 (29) |
| Septicemia | 10 (50) | 2 (11) | 4 (31) | 1 (8) | 17 (26) |
| Other | 1 (5) | 3 (16) | 2 (15) | 1 (8) | 7 (11) |
| Underlying conditions† | 3 (15) | 5 (26) | 7 (54) | 10 (77) | 25 (39) |
| Immune deficiency‡ | 2 (10) | 1 (5) | 2 (15) | 3 (23) | 8 (12) |
| Sequelae§ | 1 (5) | 1 (5) | 0 | 1 (8) | 3 (5) |
| Deaths | 2 (10) | 1 (5) | 2 (15) | 7 (54) | 12 (19) |
*Travel-associated infection included 2 visitors from Australia and South America and 3 residents who had traveled to Jamaica and Thailand and taken a Mediterranean cruise in the preceding 4 weeks.
†Underlying medical conditions included complement deficiency (1 person), diabetes mellitus (1), and systemic lupus erythematosus among persons <25 years of age; chronic liver disease (3), diabetes mellitus (1), and rheumatoid arthritis on immunosuppressive therapy (1) among persons 25–64 years of age; malignancy undergoing chemotherapy (2), diabetes mellitus (2), chronic heart disease (2), and chronic respiratory disease (1) among persons 65–84 years of age; and chronic heart disease (7), malignancy undergoing chemotherapy (2), chronic respiratory disease (1), and rheumatoid arthritis on immunosuppressive therapy (1) among persons >85 years of age.
‡Immunodeficiency included malignancy receiving chemotherapy (4 persons), autoimmune disease requiring immunosuppressant therapy (3), and complement deficiency (1).
§Sequelae included hemiparesis after meningitis in a toddler, bilateral sensorineural deafness requiring cochlear implantat after meningitis in an adult, and chronic renal insufficiency in an elderly person with septicemia.