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Volume 18, Number 11—November 2012
Research

HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina

Viviana RitaccoComments to Author , Beatriz López, Marta Ambroggi, Domingo Palmero, Bernardo Salvadores, Elida Gravina, Eduardo Mazzeo, Susana Imaz, Lucía Barrera, and National TB Laboratory Network
Author affiliations: Instituto Nacional de Enfermedades Infecciosas ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires, Argentina (V. Ritacco, B. López, E. Mazzeo, L. Barrera); Hospital “Dr. F.J. Muñiz,” Buenos Aires (M. Ambroggi, D. Palmero); Programa Provincial de Tuberculosis, Santa Fe, Argentina (B. Salvadores); Hospital Zonal General Agudos “Dr. Diego Paroissien,” La Matanza, Argentina (E. Gravina); and Instituto Nacional de Enfermedades Respiratorias “Dr. Emilio Coni” ANLIS “Dr Carlos G Malbran,” Santa Fe (S. Imaz)

Main Article

Table 2

Predictors for being in cluster and in major cluster for 787 patients with multidrug-resistant TB, Argentina, 2003–2009*

Characteristic No. patients % Patients in cluster Unadjusted OR (95% CI) Adjusted OR (95% CI)† % Patients in major cluster‡ Unadjusted OR (95% CI) Adjusted OR (95% CI)§
Age, y, n = 640

<15

 24 83.3 2.9 (0.9–8.9) ND 58.3 1.5 (0.6–3.6) ND

16–45

 495 78.6 2.1 (1.4–3.2) 2.5 (1.3–5.0) 57.9 1.5 (1.0–2.2) 1.0 (0.5–2.0)

>45

 121 63.6 1 1 48.3 1 1
Country of birth, n = 541

Argentina

 412 80.1 2.7 (1.7–3.9) 3.5 (1.9–6.4) 66.7 7.6 (4.7–12.1) 8.0 (4.3–15.0)

Other

 129 61.2 1 1 20.9 1 1
Place of diagnosis, n = 787

Hotspot¶

 634 77.9 2.1 (1.5–3.1) 1.6 (0.7–3.7) 62.3 4.2 (2.9–6.2) 5.9 (2.5–13.8)

Other

 153 62.1 1 1 28.1 1 1
HIV status, n = 604

Positive

 254 86.6 2.7 (1.7–4.1) 2.4 (1.0–5.6) 76.4 3.3 (2.-4.7) 3.7 (1.8–7.7)

Negative

 350 70.9 1 1 49.4 1 1
Previous TB, n = 557

Yes

 313 71.9 0.7 (0.5–1.0) 0.8 (0.5–1.5) 51.8 0.7 (0.5–1.0) 0.7 (0.4–1.2)

No

 244 79.1 1 1 59.4 1 1
Site of disease, n = 775

Pulmonary only

 698 74.1 0.6 (0.3–1.2) 1.4 (0.5–4.2) 55.0 0.8 (0.5–1.3) 2.7 (1.1–7.0)

Other

 77 81.8 1 1 59.7 1 1

*Boldface indicates significance. TB, tuberculosis; OR, odds ratio; ND, not done.
†Cluster model overall model fit p < 0.0001, Hosmer & Lemeshow test p = 0.5888, area under the receiver operating characteristic curve 0.723.
‡Cluster including >15 patients in the study period.
§Major cluster model overall model fit p < 0.0001, Hosmer & Lemeshow test p = 0.7766, area under the receiver operating characteristic curve 0.793.
¶Area where a multidrug-resistant outbreak was previously documented.

Main Article

1Additional members of the National TB Laboratory Network who contributed data are listed at the end of this article.

Page created: October 16, 2012
Page updated: October 16, 2012
Page reviewed: October 16, 2012
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