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Volume 20, Number 12—December 2014
Research

Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels

Danielle R. Adney, Neeltje van Doremalen, Vienna R. Brown, Trenton Bushmaker, Dana Scott, Emmie de Wit, Richard A. Bowen1Comments to Author , and Vincent J. Munster1
Author affiliations: Colorado State University, Fort Collins, Colorado, USA; (D.R. Adney, V.R. Brown, R.A. Bowen); National Institutes of Health, Hamilton, Montana, USA (N. van Doremalen, T. Bushmaker, D. Scott, E. de Wit, V.J. Munster)

Main Article

Figure 5

Histopathologic changes at 5 days postinoculation in camel 1 inoculated with MERS-CoV. Tissues were collected and stained with hematoxylin and eosin (top row). Anti-MERS-CoV immunohistochemical results (bottom row) are visible as a red-brown stain. Degeneration of the pseudostratified epithelium lining the nasal turbinate, trachea, and bronchus is indicated by the absence of goblet cells, cilia and nuclear regimentation with infiltration of neutrophils (arrows). The arrowheads indicate areas whe

Figure 5. Histopathologic changes at 5 days postinoculation in camel 1 inoculated with Middle East respiratory syndrome coronavirus (MERS-CoV). Tissues were collected and stained with hematoxylin and eosin (top row). Anti–MERS-CoV immunohistochemical results (bottom row) are visible as a red-brown stain. Degeneration of the pseudostratified epithelium lining the nasal turbinate, trachea, and bronchus is indicated by the absence of goblet cells, cilia and nuclear regimentation with infiltration of neutrophils (arrows). The arrowheads indicate areas where the cilia remained intact. Original magnification ×400.

Main Article

1These senior authors contributed equally to this article.

Page created: November 18, 2014
Page updated: November 18, 2014
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