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Volume 20, Number 3—March 2014
Dispatch

Role of Waddlia chondrophila Placental Infection in Miscarriage

David Baud1, Geneviève Goy1, Maria-Chiara Osterheld, Antony Croxatto, Nicole Borel, Yvan Vial, Andreas Pospischil, and Gilbert GreubComments to Author 
Author affiliations: University of Lausanne, Lausanne, Switzerland (D. Baud, G. Goy, A. Croxatto, G. Greub); University Hospital, Lausanne (D. Baud, Y. Vial, G. Greub, M.-C. Osterheld); University of Zürich, Zürich, Switzerland (N. Borel, A. Pospischil)

Main Article

Table 2

Characteristics of 10 women who had had miscarriages and had positive results for Waddlia chondrophila by real-time PCR*

Patient no. Age, y/race Gravida/parity No. pregnancy weeks Total Ig titer IgG titer PCR result for vaginal swab specimen PCR result for placental specimen Histologic result IHC result Other etiology
7 37/white 4/3 11.2 0 0 – + No inflammation – None found
36 3/7white 1/0 6 64 1,024 – – PMN in decidua – None found
140 34/black 1/0 6 64 128 – – PMN and plasmocytes in decidua compatible with chronic endometritis – None found
183 42/white 3/1 9 0 0 + – PMN in decidua and glandular epithelium compatible with early infection – None found
305 29/white 5/0 21 0 0 + – CAM (PMN in chorion and extension of these inflammatory cells to amnios) – Ureaplasma urealyticum
in vaginal swab specimen
357 19/Asian 2/1 8 0 0 + – Rare lymphocyte in decidua – Brucella abortus antibodies
409 42/other 3/1 10 0 0 + – PMN in subchorial fibrin and glandular epithelium compatible with early infection – HT
459 29/white 3/1 9 0 0 + – PMN and hemorrhagic necrosis – None found
523 34/other 3/1 10.5 164 0 + – No inflammation + Chlamydia trachomatis antibodies (PCR negative)
535 35/white 3/1 10 164 0 + – PMN in fibrin of decidua compatible with early infection + None found

*IHC, immunhistochemical; +, positive; –, negative; PMN, polymorphonuclear cells; CAM, chorioamnionitis; HT, hyperthyroidism.

Main Article

1These authors contributed equally to this article.

Page created: February 19, 2014
Page updated: February 19, 2014
Page reviewed: February 19, 2014
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