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Volume 20, Number 5—May 2014
Research

Streptococcus mitis Strains Causing Severe Clinical Disease in Cancer Patients

Samuel A. ShelburneComments to Author , Pranoti Sahasrabhojane, Miguel Saldana, Hui Yao, Xiaoping Su, Nicola Horstmann, Erika Thompson, and Anthony R. Flores
Author affiliations: MD Anderson Cancer Center, Houston, Texas, USA (S.A. Shelburne, P. Sahasrabhojane, M. Saldana, H. Yao, X. Su, N. Horstmann, E. Thompson); Baylor College of Medicine, Houston, Texas, USA (A.R. Flores)

Main Article

Figure 5

Streptococcus mitis strains cause dose-dependent disease in mice with neutropenia. A) Multilocus sequence analysis–generated neighbor-joining tree showing genetic relationships among all S. mitis strains. Bold branches indicate locations of the 5 strains used in the mouse model challenge experiment. Numbers 1–3 refer to clusters of S. mitis strains (defined in Figure 3). Scale bar indicates genetic distance. B) Example of mouse challenge data. Ten neutropenic Balb/C mice per dose were infected i

Figure 5. Streptococcus mitis strains cause dose-dependent disease in mice with neutropeniaA) Multilocus sequence analysis–generated neighbor-joining tree showing genetic relationships among all Smitis strainsBold branches indicate locations of the 5 strains used in the mouse model challenge experimentNumbers 1–3 refer to clusters of Smitis strains (defined in Figure 3)Scale bar indicates genetic distanceB) Example of mouse challenge dataTen neutropenic Balb/C mice per dose were infected intraperitoneally with serial 10-fold CFU dilutions of strain SVGS004 (range 107–103) and monitored for 168 h (7 d) for near-death statusPhosphate buffered saline (PBS) was injected as a controlNone of the mice injected with PBS or with the 103 dose were near death; thus, the 1 × 103 line is obscured by the PBS line on the graphSVGS, Shelburne viridans group streptococcus.

Main Article

Page created: April 16, 2014
Page updated: April 16, 2014
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