Volume 21, Number 11—November 2015
Research
Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010–2013
Table 1
Pneumococcal serotypes in isolates from adult patients with invasive pneumococcal diseases, Japan, April 2010–March 2013*
Vaccine serotype | 2010–2011, no. (%), N = 275 | 2011–2012, no. (%), N = 213 | 2012–2013, no. (%), N = 227 | p value† |
---|---|---|---|---|
PCV7 | ||||
4 | 14 (5.1) | 17 (8.0) | 7 (3.1) | 0.075 |
6B | 41 (14.9) | 24 (11.3) | 12 (5.3) | 0.003 |
9V | 7 (2.5) | 5 (2.3) | 1 (0.4) | 0.168 |
14 | 21 (7.6) | 16 (7.5) | 17 (7.5) | 0.998 |
18C | 1 (0.4) | 1 (0.5) | 1 (0.4) | ND |
19F | 14 (5.1) | 8 (3.8) | 7 (3.1) | 0.511 |
23F | 21 (7.6) | 13 (6.1) | 9 (4.0) | 0.232 |
Total |
119 (43.3) |
84 (39.4) |
54 (23.8) |
<0.001 |
PCV13 | ||||
1 | 1 (0.4) | 1 (0.5) | 0 | ND |
3 | 45 (16.4) | 27 (12.7) | 42 (18.5) | 0.226 |
5 | 0 | 0 | 1 (0.4) | ND |
6A | 11 (4.0) | 4 (1.9) | 6 (2.6) | 0.367 |
7F | 9 (3.3) | 2 (0.9) | 3 (1.3) | 0.128 |
19A | 18 (6.5) | 11 (5.2) | 17 (7.5) | 0.593 |
Total |
203 (73.8) |
129 (60.6) |
123 (54.2) |
<0.001 |
PPSV23 | ||||
10A | 10 (3.6) | 8 (3.8) | 11 (4.8) | 0.754 |
11A | 3 (1.1) | 8 (3.8) | 5 (2.2) | 0.142 |
15B | 3 (1.1) | 4 (1.9) | 5 (2.2) | 0.605 |
22F | 10 (3.6) | 19 (8.9) | 18 (7.9) | 0.040 |
Other‡ | 8 (2.9) | 1 (0.5) | 8 (3.5) | 0.082 |
Total |
226 (82.2) |
165 (77.5) |
164 (72.2) |
0.036 |
Nonvaccine serotype | ||||
6C | 13 (4.7) | 12 (5.6) | 17 (7.5) | 0.407 |
15A | 6 (2.2) | 10 (4.7) | 8 (3.5) | 0.310 |
15C | 0 | 4 (1.9) | 4 (1.8) | ND |
23A | 2 (0.7) | 8 (3.8) | 8 (3.5) | 0.053 |
35B | 7 (2.5) | 6 (2.8) | 9 (4.0) | 0.626 |
37 | 3 (1.1) | 0 | 1 (0.4) | ND |
38 | 3 (1.1) | 2 (0.9) | 3 (1.3) | 0.928 |
Other§ | 3 (1.1) | 2 (0.9) | 5 (2.2) | 0.454 |
Total |
37 (13.5) |
44 (20.7) |
55 (24.2) |
0.007 |
Nontypeable¶ | 1 (0.4) | 0 | 2 (0.9) |
*Years run from April 1 to March 31 of the following year. ND, not determined because of a low number of strains.
†p values characterize comparisons of 2010–2011, 2011–2012, and 2012–2013.
‡Serotypes 12F, 20, and 33F.
§Serotypes 6D, 7C, 16F, 18B, 24F, and 34.
¶These serotypes were excluded from the statistical analysis because they were unclassifiable.