Volume 21, Number 11—November 2015
Research
Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010–2013
Kimiko Ubukata
, Naoko Chiba, Shigeo Hanada, Miyuki Morozumi, Takeaki Wajima, Michi Shouji, Satoshi Iwata, and Invasive Pneumococcal Diseases Surveillance Study Group
, Naoko Chiba, Shigeo Hanada, Miyuki Morozumi, Takeaki Wajima, Michi Shouji, Satoshi Iwata, and Invasive Pneumococcal Diseases Surveillance Study Group
Table 5
Serotypes, resistance genotypes, and multilocus sequence type for non-PCV13 serotype isolates from adults with invasive pneumococcal diseases, Japan, April 2010–March 2013*
| Serotype (total no. isolates) | No. isolates, N = 92 | Penicillin resistance genotype | Macrolide resistance gene | Clonal complex | ST | Earliest report of same ST† |
|
|---|---|---|---|---|---|---|---|
| Year | Country (city) | ||||||
| 6C (17) | 1 | gPISP(pbp2x+2b) | erm(B) | 315 | 386 | 1996 | Portugal (Lisbon) |
| 4 | gPISP(pbp2x) | erm(B) | 2924 | 2924 | 2003 | Japan (Hyogo) | |
| 2 | gPISP(pbp2x) | erm(B) | 2924 | 6183 | 2008 | Japan (Kanagawa) | |
| 1 | gPISP(pbp2x) | erm(B) | 2924 | 9336‡ | 2012 | Japan (Fukuoka) | |
| 1 | gPSSP | Non | 473 | 473 | 1994 | England (Oxford) | |
| 3 | gPISP(pbp2x+2b) | erm(B) | 156 | 5241 | 2008 | Japan (Kumamoto) | |
| 2 | gPISP(pbp2x+2b) | mef(A) | 5832 | 5025‡ | 2012 | Japan (Kanagawa) | |
| 2 | gPISP(pbp2x+2b) | mef(A) or erm(B) | 5832 | 5832 | 2009 | Japan (Chiba) | |
| 1 |
gPISP(pbp2x+2b) |
mef(A)+erm(B) |
5832 |
5832 |
2009 |
Japan (Chiba) |
|
| 6D (1) |
1 |
gPRSP |
mef(A) |
81 |
282 |
1996; 2008 |
Vietnam [23F];
South Korea [6D] |
| 10A (11) | 1 | gPISP(pbp2x) | Non | 156 | 1263 | 1998 | USA (Arizona/New Mexico) |
| 1 | gPISP(pbp2x) | Non | 156 | 3395‡ | 2012 | Japan (Toyama) | |
| 8 | gPISP(pbp2x) | erm(B) | 113 | 5236 | 2007 | Japan (Kanagawa) | |
| 1 |
gPISP(pbp1a+2x) |
erm(B) |
113 |
3078‡ |
2012 |
Japan (Yamaguchi) |
|
| 11A (5) | 1 | gPSSP | mef(A) | 99 | 99 | 2007 | South Korea (Seoul) |
| 4 |
gPISP(pbp2x) |
mef(A)+erm(B) |
99 |
99 |
2007 |
South Korea (Seoul) |
|
| 15A (8) | 4 | gPISP(pbp1a+2x) | erm(B) | 63 | 63 | 1992 | [Sweden15A-25] |
| 4 |
gPRSP |
erm(B) |
63 |
63 |
1992 |
[Sweden15A-25] |
|
| 15B (6) | 1 | gPSSP | mef(A) | 199 | 199 | 1987 | [Netherlands15B-37] |
| 3 | gPISP(pbp2x) | erm(B) | 199 | 199 | 1987 | [Netherlands15B-37] | |
| 1 | gPISP(pbp2x) | erm(B) | 199 | 5609‡ | 2012 | Japan (Tokyo) | |
| 1 |
gPRSP |
erm(B) |
81 |
83 |
1997
2007 |
Taiwan [23F]
South Korea [15] |
|
| 15C (4) | 1 | gPISP(pbp2x) | erm(B) | 199 | 199 | 1987 | [Netherlands15B-37] |
| 2 | gPISP(pbp1a+2x) | erm(B) | 199 | 199 | 1987 | [Netherlands15B-37] | |
| 1 |
gPRSP |
erm(B) |
81 |
6138‡ |
2013 |
Japan (Tokyo) |
|
| 16F (1) |
1 |
gPRSP |
mef(A) |
3117 |
8351‡ |
2011 |
Japan (Mie) |
| 20 (3) |
3 |
gPSSP |
erm(B) |
4745 |
4745 |
2005 |
China (Wuhan, Hubei) |
| 22F (18) | 1 | gPSSP | Non | 433 | 433 | 1997 | Poland (center) |
| 4 | gPISP(pbp2x) | Non | 433 | 433 | 1997 | Poland (center) | |
| 10 | gPISP(pbp2x) | mef(A) or erm(B) | 433 | 433 | 1997 | Poland (center) | |
| 1 | gPISP(pbp2x) | mef(A) | 113 | 5236 | 2007 | Japan (Kanagawa) | |
| 2 |
gPISP(pbp2x) |
erm(B) |
113 |
7158 |
2007 |
Japan (Aichi) |
|
| 23A (9) | 2 | gPISP(pbp2x+2b) | erm(B) | 156 | 338 | 1995 | [Colombia23F-26] |
| 4 | gPISP(pbp2x+2b) | erm(B) | 156 | 5242 | 2009 | Japan (Kumamoto) | |
| 2 | gPISP(pbp2x+2b) | erm(B) | 156 | 5246 | 2008 | Japan (Niigata) | |
| 1 |
gPRSP |
erm(B) |
156 |
9619‡ |
2011 |
Japan (Toyama) |
|
| 35B (9) | 2 | gPSSP | erm(B) | 1816 | 2755 | 2004 | China (Shanghai) |
| 2 | gPISP(pbp2x) | mef(A) or erm(B) | 1816 | 2755 | 2004 | China (Shanghai) | |
| 1 | gPRSP | Non | 558 | 558 | 1999 | USA (New York) [35B] | |
| 4 | gPRSP | mef(A) or erm(B) | 558 | 558 | 1999 | USA (New York) [35B] | |
*PCV13, 13-valent pneumococcal conjugate vaccine; ST, sequence type. Brackets in final column represent clones reported in the Pneumococcal Molecular Epidemiology Network Clone Collection (http://web1.sph.emory.edu/PMEN/index.html).
†Earliest year and first location are shown for the applicable ST registered in the Multilocus Sequence Typing website (http://spneumoniae.mlst.net).
‡Identified as a new ST in this study.
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Page updated: October 16, 2015
Page reviewed: October 16, 2015
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