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Volume 21, Number 12—December 2015
CME ACTIVITY - Dispatch

Life-Threatening Sochi Virus Infections, Russia

Detlev H. KrugerComments to Author , Evgeniy A. Tkachenko, Vyacheslav G. Morozov, Yulia V. Yunicheva, Olga M. Pilikova, Gennadiy Malkin, Aydar A. Ishmukhametov, Patrick Heinemann, Peter T. Witkowski, Boris Klempa, and Tamara K. Dzagurova
Author affiliations: Charité School of Medicine, Berlin, Germany (D.H. Kruger, P. Heinemann, P.T. Witkowski, B. Klempa); Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia (E.A. Tkachenko, G. Malkin, A.A. Ishmukhametov, T.K. Dzagurova); Medical State University, Samara, Russia (V.G. Morozov); Anti-Plague Stations, Sochi, Russia (Y.V. Yunicheva); Anti-Plague Stations, Novorossiysk, Russia (O.M. Pilikova); Slovak Academy of Sciences, Bratislava, Slovakia (B. Klempa)

Main Article

Table 2

Characteristics of 9 deceased patients with Sochi virus infection, Russia*

Patient no. Age, y/sex Hospitalized, no. d after onset GI symptoms Max serum creatinine, μmol/L† Min platelet count, × 109/L‡ Died, no. d after onset Clinical and postmortem findings
23
 33/M
 5
 No
 148
 70
 8
 Pneumonia; renal, cardiovascular, multiorgan failure; multiple internal hemorrhages, edema
29
 29/M
 Same day
 Yes
 282
 115
 6
 Renal, cardiovascular, multiorgan failure; multiple internal hemorrhages, edema
30
 47/F
 5
 Yes
 391
 38
 12
 Renal, lung failure; shock; coagulation disturbance; hemorrhagic gastroenteritis; multiple internal hemorrhages, edema
34
 53/M
 3
 Yes
 250
 110
 10
 Multiorgan failure; coagulation disturbances; multiple internal hemorrhages
42
 30/M
 14
 Yes
 186
 67
 16
 Uremic coma; multiorgan failure; multiple internal hemorrhages
47§
 41/M
 Died before hospitalization
 Yes
 NR
 NR
 3
 Renal failure; multiple internal hemorrhages, edema
48§
 19/M
 4
 Yes
 192
 54
 6
 Renal, cardiovascular failure; RDS, DIC syndrome; bleedings in pituitary, adrenal gland, intestinum, etc.
56
 35/F
 4
 Yes
 410
 49
 6
 Cardiovascular, renal, lung, liver failure; renal tubular necrosis; lung, brain edema
59 50/M 5 Yes 310 3 7 Renal,cardiovascular failure; RDS; multiple internal hemorrhages; pleurorrhea; lung, brain edema

*DIC, disseminated intravascular coagulation; GI, gastrointestinal; max, maximum; min, minimum; RDS, respiratory distress syndrome; NR, not reported.
†Reference range <96 μmol/L for female patients, <110 μmol/L for male patients.
‡Reference range 150–400 × 109/L
§Patient no. 47 was the father in-law of patient no. 48; both lived in the same rural residence.

Main Article

Page created: November 13, 2015
Page updated: November 13, 2015
Page reviewed: November 13, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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